| Company Name: |
Jinan Chuanbei Biotechnology Co., Ltd Gold
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| Tel: |
18654547380; 15269175648 |
| Email: |
qingyan7590@163.com |
| Products Intro: |
Product Name:BLU-451(LNG451)
CAS:2769954-39-2
Purity:99.0% Package:5g;50g;100g
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| Company Name: |
Changzhou Chenhong Biotechnology Co., Ltd.
|
| Tel: |
0519-85788828 13775037613 |
| Email: |
sales@chemrenpharm.com |
| Products Intro: |
Product Name:BLU-451
CAS:2769954-39-2
Purity:99% Package:50mg;100mg;250mg;500mg;1g;5g
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| Company Name: |
Chunchuang (Wuhan) Technology Co., Ltd
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| Tel: |
15727060112 |
| Email: |
yutianchun2007@126.com |
| Products Intro: |
Product Name:2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]-
CAS:2769954-39-2
Purity:99.5+ Package:100g/RMB 1000
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| | 2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Basic information |
| | 2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | form | Solid | | pka | 12.22±0.70(Predicted) | | color | White to off-white |
| | 2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Usage And Synthesis |
| Uses | Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion[1]. | | References | [1] Zhou Y, et al., Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis. Explor Target Antitumor Ther. 2024;5(3):568-580. DOI:10.37349/etat.2024.00236 |
| | 2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Preparation Products And Raw materials |
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