| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:HDAC6-IN-11
CAS:2409072-27-9
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
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2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- manufacturers
- HDAC6-IN-11
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- $1980.00 / 50mg
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2025-10-27
- CAS:2409072-27-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- Basic information |
| | 2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- Chemical Properties |
| density | 1.314±0.06 g/cm3(Predicted) | | pka | 8.23±0.23(Predicted) |
| | 2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- Usage And Synthesis |
| Uses | HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1]. | | IC 50 | HDAC6: 20.7 nM (IC50); HDAC8: 7750 nM (IC50) | | References | [1] Shih-Wei Wang, et al. Synthesis and biological evaluation of 2-quinolineacrylamides. Bioorg Med Chem. 2020 Feb 1;28(3):115250. DOI:10.1016/j.bmc.2019.115250 |
| | 2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- Preparation Products And Raw materials |
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