多粘菌素B1
| 中文名称 | 多粘菌素B1 |
|---|---|
| 中文同义词 | 多粘菌素B1;多黏菌素 B1;多粘菌素B1 POLYMYXIN B1 |
| 英文名称 | polymyxin B(1) |
| 英文同义词 | polymyxin B(1);(-)-N2-[[(6S)-6-Methyloctanoyl]-L-A2bu-L-Thr-L-A2bu-]cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-);(6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;polymyxin B1Q: What is polymyxin B1 Q: What is the CAS Number of polymyxin B1;Glucosamine Hydrochloride Impurity 33 |
| CAS号 | 4135-11-9 |
| 分子式 | C56H98N16O13 |
| 分子量 | 1203.48 |
| EINECS号 | |
| 相关类别 | 化药杂质-多粘菌素 |
| Mol文件 | 4135-11-9.mol |
| 结构式 |  |
多粘菌素B1 性质
| 沸点 | 838.79°C (rough estimate) |
|---|---|
| 密度 | 1.0500 (rough estimate) |
| 折射率 | 1.6200 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | PBS（pH 7.2）：2 mg/ml |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 13.08±0.70(Predicted) |
Polymyxin B1 has antimicrobial activity that againsts
Pseudomonas aeruginosa
ATCC 27853,
Acinetobacter baumannii
ATCC BAA 747,
Klebsiella pneumoniae
ATCC 13883,
P. aeruginosa
9019,
A. baumannii
1261 and
K. pneumoniae
VM9 isolates with MIC values of 4 μg/mL, 2 μg/mL, 2 μg/mL, 4 μg/mL, 4 μg/mL and 2 μg/mL, respectively.
Polymyxin B1 strongly inhibits protein synthesis in yeast, and in
E. coli
and
S. aureus
.
The pharmacokinetics of Polymyxin B1 is investigated in a rat model following intravenous administration (0.8 mg/kg). The area under the concentration-time curve for Polymyxins B1 is greater than those of colistins A and B. Colistin A colistin B. The clearance value of Polymyxins B1 is 2.39 mL/min/kg, the plasma protein binding is 82.3%, the elimination half-life is 79.5 min and the AUC 0-∞ is 365 mg•min/L.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-A0248A | polymyxin B(1) Polymyxin B1 | 4135-11-9 | 1mg | 2400元 |