2,5-二羟基-4-甲氧基二苯甲酮
| 中文名称 | 2,5-二羟基-4-甲氧基二苯甲酮 |
|---|---|
| 中文同义词 | 2,5-二羟基-4-甲氧基二苯甲酮 |
| 英文名称 | Cearoin |
| 英文同义词 | Cearoin;Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone;(2,5-dihydroxy-4-methoxyphenyl)phenylmethanone;Methanone, (2,5-dihydroxy-4-methoxyphenyl)phenyl-;2,5-Dihydroxy-4-methoxybenzophenone |
| CAS号 | 52811-37-7 |
| 分子式 | C14H12O4 |
| 分子量 | 244.24 |
| EINECS号 | |
| 相关类别 | 其它酚类 |
| Mol文件 | 52811-37-7.mol |
| 结构式 |  |
2,5-二羟基-4-甲氧基二苯甲酮 性质
| 熔点 | 188 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 沸点 | 443.8±45.0 °C(Predicted) |
| 密度 | 1.296±0.06 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 酸度系数(pKa) | 8.25±0.48(Predicted) |
Cearoin 可从Dalbergia odorifera中分离，通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
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ERK
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ROS
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Autophagy
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Apoptosis
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Cearoin (10-80 μM) induces cell death in a dose-dependent manner.
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells.
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process.
Cell Viability Assay
| Cell Line: | Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 1, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 6 or 12 hours |
| Result: | Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. |
Western Blot Analysis
| Cell Line: | Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 12 hours |
| Result: |
Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-N8418 | 2,5-二羟基-4-甲氧基二苯甲酮 Cearoin | 52811-37-7 | 1mg | 2500元 |