蜂斗菜螺内酯
中文名称 | 蜂斗菜螺内酯 |
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中文同义词 | 蜂斗菜螺内酯;蜂斗菜内酯B;螺内酯(安体舒通)杂质16 |
英文名称 | Fukinolide |
英文同义词 | Fukinolide;(-)-Bakkenolide B;(1'R,3R,7'aβ)-1'β-Acetoxy-3'aβ,4'β-dimethyl-4-methylene-7'α-[[(2Z)-2-methyl-2-butenoyl]oxy]spiro[oxolane-3,2'-hydrindane]-2-one;(Z)-2-Methyl-2-butenoic acid [(3R,3'aα)-3'α-acetoxy-4,5,1',3',3'a,4',5',6',7',7'a-decahydro-7'α,7'aα-dimethyl-4-methylene-2-oxospiro[furan-3(2H),2'-[2H]inden]-4'β-yl] ester;Bakkenolide B;2-Butenoic acid, 2-methyl-, (2'R,3'R,3'aR,4'S,7'S,7'aR)-3'-(acetyloxy)decahydro-7',7'a-dimethyl-4-methylene-2-oxospiro[furan-3(2H),2'-[2H]inden]-4'-yl ester, (2Z)-;Spironolactone EP Impurity 16 |
CAS号 | 18455-98-6 |
分子式 | C22H30O6 |
分子量 | 390.47 |
EINECS号 | |
相关类别 | 倍半萜 |
Mol文件 | 18455-98-6.mol |
结构式 |
蜂斗菜螺内酯 性质
熔点 | 101-102 °C |
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沸点 | 503.0±50.0 °C(Predicted) |
密度 | 1.16±0.1 g/cm3(Predicted) |
Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner.Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages.
Western Blot Analysis
Cell Line: | Mouse peritoneal macrophages |
Concentration: | 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml |
Incubation Time: | 1 h later stimulated with LPS |
Result: | Decreased iNOS and cox-2 protein expression. |
Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice.
Animal Model: | Ovalbumin-induced asthma mice |
Dosage: | 1 mg/ml |
Administration: | Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30 |
Result: | Exhibited anti-allergic effects in mice. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2022/09/18 | HY-N7292 | 蜂斗菜螺内酯 Bakkenolide B | 18455-98-6 | 1mg | 4600元 |
2022/09/18 | HY-N7292 | 蜂斗菜螺内酯 Bakkenolide B | 18455-98-6 | 5mg | 13200元 |