盐酸酚苄明
中文名称 | 盐酸酚苄明 |
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中文同义词 | N-(1-甲基-2-苯氧乙基)-N-(2-氯乙基)苯甲胺盐酸盐;盐酸苯氧苄胺;盐酸酚苄明;苯苄胺;苯氧苄胺;酚苄胺;酚苄明盐酸盐;N-(2-氯乙基)-N-(1-甲基-2-苯氧乙基)苄胺盐酸盐 |
英文名称 | Phenoxybenzamine hydrochloride |
英文同义词 | benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride;dibenzyran;n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride;phenoxybenzamidehydrochloride;BENZENE METHANAMINE HYDROCHLORIDE;DIBENZYLINE HYDROCHLORIDE;N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE;PHENOXYBENZAMINE HYDROCHLORIDE |
CAS号 | 63-92-3 |
分子式 | C18H22ClNO.ClH |
分子量 | 340.29 |
EINECS号 | 200-569-7 |
相关类别 | 原料药;医药原料;G蛋白偶联受体&G蛋白;中间体;小分子抑制剂;医用原料;细胞生物学试剂;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;DIBENZYLINE;科研试剂;原料;化学试剂;日用化学品;医药原料药 |
Mol文件 | 63-92-3.mol |
结构式 |
盐酸酚苄明 性质
熔点 | 137.5°C |
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储存条件 | 15-25°C |
溶解度 | 溶于乙醇、DMSO、二甲基甲酰胺(DMF)等有机溶剂。 |
形态 | 粉末 |
酸度系数(pKa) | pKa 4.4 (Uncertain) |
颜色 | 白色 |
水溶解性 | <0.01 g/100 mL at 18.5 ºC |
Merck | 14,7256 |
稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20°C 下储存长达 3 个月。 |
CAS 数据库 | 63-92-3(CAS DataBase Reference) |
(IARC)致癌物分类 | 2B (Vol. 24, Sup 7) 1987 |
EPA化学物质信息 | N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3) |
Target | Value |
α-adrenergic receptor |
The IC 50 (100 nM) derived from the blockade of [ 3 H]yohimbine binding by Phenoxybenzamine hydrochloride is significantly less than the IC 50 (550 nM) for the corresponding reversal by Phenoxybenzamine hydrochloride of the effects of norepinephrine on cyclic AMP accumulation. Phenoxybenzamine hydrochloride (50 nM) in conbination with Phenoxybenzamine hydrochloridetolamine (1000 nM) enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with pretreatment with Phenoxybenzamine hydrochloride (50 nM) alone in endothelium-intact aortae. Combined treatment with either dexmedetomidine (300 or 1000 nM) and Phenoxybenzamine hydrochloride (50 nM) or Phenoxybenzamine hydrochloridetolamine (1000 nM) and Phenoxybenzamine hydrochloride (50 nM) enhance Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with Phenoxybenzamine hydrochloride alone (50 nM). In addition, combined treatment with Phenoxybenzamine hydrochloridetolamine and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride combined treatment. Combined treatment with high concentrations of dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with combined treatment with low concentrations of dexmedetomidine (300 nM) and Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride (0.1-100 μM) inhibits glioma proliferation, migration, and invasion and suppresses the tumorigenesis capacity. Phenoxybenzamine hydrochloride also inhibits self-renewal of glioma stem-like cells. Phenoxybenzamine hydrochloride activates LINGO-1 and inhibits the TrkB-Akt pathway. Phenoxybenzamine hydrochloride (0.1 μM-1 mM) preserves primary neurons within the CA1, CA3 and dentate gyrus and produces a robust neuroprotective effect, and prevents neuronal death from OGD in all regions of the hippocampus when delivered at 2, 4, and 8 h post-OGD at 100 μM.
Phenoxybenzamine hydrochloride (20 nM, s.c.) effectively suppresses the tumorigenesis of glioma cells in mice and the cell density in Phenoxybenzamine hydrochloride-U87MG xenografts decreases significantly. Phenoxybenzamine hydrochloride (1 mg/kg, i.v.) treated rats shows significant improvements in NSS and foot fault scoring.
安全信息
危险品标志 | Xn |
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危险类别码 | 22-40 |
安全说明 | 22-36/37/39-45 |
WGK Germany | 3 |
RTECS号 | DP3750000 |
海关编码 | 2922299000 |