L-硒代蛋氨酸

L-硒代蛋氨酸

中文名称L-硒代蛋氨酸
中文同义词L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINE L-硒代蛋氨酸
英文名称L-Selenomethionine
英文同义词(S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID;SELENOMETHIONINE, L-(+)-;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINE;The L-selenoMethionine;L-SELENOMETHINONINE
CAS号3211-76-5
分子式C5H11NO2Se
分子量196.11
EINECS号608-705-0
相关类别医药原料药;化学试剂;氨基酸类;细胞信号和神经生物学;食品添加剂;氨基酸;新材料;对照品;功能性物质-硒代蛋氨酸;生化试剂-氨基酸类;化工;L-硒代蛋氨酸;化工原料;原料;医药原料;医用原料;食品添加;优势产品;Amino Acid Derivatives;Methionine [Met, M];Amino Acids;Antioxidant;Biochemistry;Biological-modified Amino Acids;Classes of Metal Compounds;Se (Selenium) Compounds;Semimetal Compounds;Seleno Amino Acid;amino acid;饲料添加剂;其他;高纯试剂;非天然氨基酸;化学产品;合成材料中间体
Mol文件3211-76-5.mol
结构式L-硒代蛋氨酸 结构式

L-硒代蛋氨酸 性质

熔点265 °C
比旋光度18 º (c=1, 1N HCl)
沸点320.8±37.0 °C(Predicted)
折射率18 ° (C=0.5, 2mol/L HCl)
储存条件-20°C
溶解度H2O:50 mg/mL
形态粉末
酸度系数(pKa)2.26±0.10(Predicted)
颜色白色至类白色
水溶解性soluble
Merck14,8441
InChIInChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyRJFAYQIBOAGBLC-BYPYZUCNSA-N
SMILESC(O)(=O)[C@@H](N)CC[Se]C
LogP0.152 (est)
CAS 数据库3211-76-5(CAS DataBase Reference)

L-硒代蛋氨酸 用途与合成方法

L-SelenoMethionine 是 Selenomethionine 的 L-异构体,是硒的主要天然食物形式。L-SelenoMethionine 是一种癌症化学预防剂,可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine 还可以增加谷胱甘肽过氧化物酶的表达。

Human Endogenous Metabolite

L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells.
L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells.
L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells.
L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation.

Cell Viability Assay

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 1, 5, 10, 50, 100, 500 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).

Apoptosis Analysis

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells.
Promoted the PARP cleavage in prostate cancer cells.

Cell Cycle Analysis

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.

RT-PCR

Cell Line: Human thyroid epithelial cells (HTori-3)
Concentration: 5 μM
Incubation Time: 24 hours
Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.

L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.

用途 
可以用于蛋白质的结构分析。拿此产品来饲养细菌,这样最终形成的蛋白质里的特定位置就会被硒所取代,便于结构测定

安全信息

危险品标志T,N
危险类别码23/25-33-50/53
安全说明20/21-28-45-60-61-28A
危险品运输编号UN 3283 6.1/PG 2
WGK Germany3
RTECS号EK7713840
F10
危险等级6.1
包装类别III
海关编码29309090

MSDS信息

提供商 语言
英文
英文
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-B1000AL-硒代蛋氨酸
L-SelenoMethionine
3211-76-5100mg550元
2024/01/25HY-B1000AL-硒代蛋氨酸
L-SelenoMethionine
3211-76-510mM * 1mLin Water605元
"L-硒代蛋氨酸"相关产品信息
FMOC-SELENOMETHIONINE 硒[75SE]蛋氨酸 DL-硒代蛋氨酸 L-硒代蛋氨酸 硒代蛋胺基乙酸 L-硒代甲硫氨酸 硒蛋氨酸(DL-硒代蛋氨酸)
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