依来多辛
| 中文名称 | 依来多辛 |
|---|---|
| 中文同义词 | 依来多辛;麝香蛸素;醋酸依来多辛 ELEDOISINACETATE;醋酸依来多辛 69-25-0;醋酸依来多辛;ELEDOISIN ACETATE 醋酸依来多辛;章鱼唾腺精, >99%;章鱼唾腺精 |
| 英文名称 | Eledoisin |
| 英文同义词 | eledonepeptide;ELEDOISIN;GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;5-oxo-l-prolyl-l-prolyl-l-seryl-l-lysyl-l-aspartyl-l-alanyl-l-phenylalanyl-l-isoleucylglycyl-l-leucyl-l-methioninamide;PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;PYR-PSKDAFIGLM-NH2;PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2;ELEDOSIN |
| CAS号 | 69-25-0 |
| 分子式 | C54H85N13O15S |
| 分子量 | 1188.4 |
| EINECS号 | 251-228-4 |
| 相关类别 | 多肽;医药原料药;医药原料;proteins;Peptide |
| Mol文件 | 69-25-0.mol |
| 结构式 |  |
依来多辛 性质
| 熔点 | 230 °C (decomp) |
|---|---|
| 沸点 | 1618.1±65.0 °C(Predicted) |
| 密度 | 1.289±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | DMF：15 mg/ml； DMSO：20 mg/ml； DMSO:PBS (pH 7.2) (1:20)：0.04 mg/ml |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.19±0.10(Predicted) |
依来多辛是 NK2 和 NK3 受体的特异性激动剂。
NK2 and NK3 receptors.
Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively.
Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | JX8688000 |
| 海关编码 | 3504009000 |
| 提供商 | 语言 |
|---|---|
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英文
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