Α-(三氯甲基)-4-吡啶乙醇
| 中文名称 | Α-(三氯甲基)-4-吡啶乙醇 |
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| 中文同义词 | Α-(三氯甲基)-4-吡啶乙醇;ALPHA-(三氯甲基)-4-吡啶乙醇;Α-(三氯甲基)-4-吡啶乙醇;化合物 T12413;PETCM,半胱氨酸蛋白酶-3激活剂 |
| 英文名称 | ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL |
| 英文同义词 | PETCM;APOPTOSIS ACTIVATOR I;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;a-(Trichloromethyl)-4-pyridineethanol;α-(Trichloromethyl)-4-pyridineethanol;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane |
| CAS号 | 10129-56-3 |
| 分子式 | C8H8Cl3NO |
| 分子量 | 240.51 |
| EINECS号 | |
| 相关类别 | Caspase/Related products. |
| Mol文件 | 10129-56-3.mol |
| 结构式 |  |
Α-(三氯甲基)-4-吡啶乙醇 性质
| 沸点 | 342.2±37.0 °C(Predicted) |
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| 密度 | 1.465±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | DMSO：22 mg/mL，可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.07±0.20(Predicted) |
PETCM 是 caspase-3 的激活剂，以细胞色素 c (cyto c) 依赖的方式起作用。PETCM 可促进 Apaf-1 低聚化，可诱导 HeLa 细胞的凋亡 (apoptosis)。
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Caspase 3
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PETCM (0.1-0.5 mM) stimulates caspase-3 activity (DEVD activity) of HeLa S-100 in a dose-dependent manner.And 0.2 mM PETCM is more efficient in activating caspase-3 than 1 mM dATP.PETCM (0.2 mM; 1 hour) drives apoptosome formation. Apaf-1 in a normal HeLa cell S-100 fraction is in an inactive monomeric form. After 1 mM dATP, most of the Apaf-1 shifted to a size of 1 million daltons. After the S-100 fraction with 0.2 mM PETCM, Apaf-1 exhibits a similar shift. And the efficiency of apoptosome formation was better with 0.2 mM PETCM.PETCM (0.2 mM; 1 hour) can antagonize the inhibitory activity of ProT reduced caspase-3 activation in in HeLa cells.
Western Blot Analysis
| Cell Line: | HeLa cells |
| Concentration: | 0.2 mM |
| Incubation Time: | 1 hour |
| Result: | Increased apoptosome formation. |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-103349 | Α-(三氯甲基)-4-吡啶乙醇 PETCM | 10129-56-3 | 5mg | 500元 |
| 2024/01/25 | HY-103349 | PETCM | 10 mM * 1 mLin DMSO | 550元 |