6-HYDROXY-2-NAPHTHYL DISULFIDE

6-HYDROXY-2-NAPHTHYL DISULFIDE Suppliers list
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Products Intro: Product Name:PIR 3.5;6,6′-Dithiodi(2-naphthol)
CAS:6088-51-3
Package:10 mg;100 mg;2 mg;200 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
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Products Intro: Product Name:Bis(6-Hydroxy-2-Naphthyl) Disulfide
CAS:6088-51-3
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Hot selling
Company Name: Alfa Chemistry
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Products Intro: Product Name:6-Hydroxy-2-naphthyl disulfide
CAS:6088-51-3
Purity:98% Remarks:https://materials.alfachemic.com/product/6-hydroxy-2-naphthyl-disulfide-cas-6088-51-3-191987.html
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Products Intro: Product Name:6-HYDROXY-2-NAPHTHYL DISULFIDE
CAS:6088-51-3
Purity:99% Package:25KG
Company Name: GIHI CHEMICALS CO.,LIMITED
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Products Intro: Product Name:Bis(6-Hydroxy-2-Naphthyl) Disulfide
CAS:6088-51-3
Purity:99 Package:5KG;1KG,25kg
6-HYDROXY-2-NAPHTHYL DISULFIDE Basic information
Product Name:6-HYDROXY-2-NAPHTHYL DISULFIDE
Synonyms:6,6'-Dithiodi-2-naphthtol;PIR 3.5;DDD (Analytical);DDD 6,6'-Dihydroxy-2,2'-dinaphthyl Disulfide 6-Hydroxy-2-naphthyl Disulfide;2-Naphthalenol,6,6'-dithiobis-;6,6'Bis(2-hydroxy-6-naphthyl) disulfide;TIMTEC-BB SBB005947
CAS:6088-51-3
MF:C20H14O2S2
MW:350.45
EINECS:228-025-4
Product Categories:Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry
Mol File:6088-51-3.mol
6-HYDROXY-2-NAPHTHYL DISULFIDE Structure
6-HYDROXY-2-NAPHTHYL DISULFIDE Chemical Properties
Melting point 226 °C
Boiling point 597.5±25.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility <26.28mg/ml in DMSO
form powder to crystal
pka8.93±0.40(Predicted)
color White to Brown
Merck 14,2840
CAS DataBase Reference6088-51-3(CAS DataBase Reference)
EPA Substance Registry System2-Naphthalenol, 6,6'-dithiobis- (6088-51-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 2908990090
MSDS Information
ProviderLanguage
SigmaAldrich English
6-HYDROXY-2-NAPHTHYL DISULFIDE Usage And Synthesis
DescriptionDDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity.
UsesFor determination of protein-bound sulfhydryl groups.
Purification MethodsIt crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.]
Toxicity evaluationAnimal Studies. DDD is less acutely toxic than DDT (29), with an oral LD50 of 3400 to 4000 mg/kg in the rat and a dermal LD50 ca. 1200 mg/kg in the rabbit. In a 2-year chronic dietary study in the rat, a LOEL of 100 ppm (5 mg/kg/day) was quoted for tissue damage, similar to that produced by DDT.
Human Studies. Most of the studies conducted in humans have used the o,p -isomer of DDD. This has been used as a drug, with medical and veterinary uses, for the treatment of Cushing’s syndrome and adrenal carcinoma, under the generic name of mitotane. After oral ingestion, o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the adrenal appears to be species-dependent, however, causing gross atrophy in the dog and reducing corticosteroid production without pathological effects in other mammals, including humans.
6-HYDROXY-2-NAPHTHYL DISULFIDE Preparation Products And Raw materials
Raw materials2-Naphthalenol, 6-mercapto-
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