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L-Homophe-OH

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Company Name: DONBOO AMINO ACID COMPANY
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Products Intro: Product Name:L-Homophenylalanine
CAS:943-73-7
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Company Name: Sichuan HongRi Pharma-Tech Co.,Ltd
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Products Intro: Product Name:L-Homophe-OH
CAS:943-73-7
Purity:99% Package:1kg;|10kg;|100kg
Company Name: Hebei Mojin Biotechnology Co., Ltd
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Products Intro: Product Name:L-Homophenylalanine
CAS:943-73-7
Purity:99% Package:25KG
Company Name: Chongqing Zhihe Biopharmaceutical Co., Ltd.
Tel: +86-18580541567 +86-17782035140
Email: sales@zhswyy.com
Products Intro: Product Name:L-Homophe-OH
CAS:943-73-7
Purity:99 Package:1kg;|5kg;|25kg
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:(+)-2-Amino-4-phenylbutyric acid
CAS:943-73-7
Purity:98%(min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg

L-Homophe-OH manufacturers

  • L-Homophe-OH
  • L-Homophe-OH pictures
  • $0.00/ kg
  • 2024-03-28
  • CAS:943-73-7
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1T+
  • L-Homophe-OH
  • L-Homophe-OH pictures
  • $0.00 / 1kg
  • 2024-03-27
  • CAS:943-73-7
  • Min. Order: 0.10000000149011612kg
  • Purity: 99
  • Supply Ability: 20tons
  • L-Homophenylalanine
  • L-Homophenylalanine pictures
  • $0.00 / 25KG
  • 2023-10-16
  • CAS:943-73-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50000KG/month
L-Homophe-OH Basic information
Description References
Product Name:L-Homophe-OH
Synonyms:(+)-2-Amino-4-phenylbutyric acid,98%;S)-α-Amino-benzenebutanoic acid;L-(S)-Homophenylalanine.HCl;L-Homophenylalanine ,98%;H-L-HPA-OH;Benzenebutanoicacid, a-aMino-, (aS)-;H-HoMophe-OH(HoMophenylalanine);RARECHEM BK PT 0049
CAS:943-73-7
MF:C10H13NO2
MW:179.22
EINECS:213-403-3
Product Categories:API intermediates;Homophenylalanine [Hph];Chiral Compounds;Amino Acids & Derivatives;Aromatics;Amino Acids 13C, 2H, 15N;Chiral Compound;Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids
Mol File:943-73-7.mol
L-Homophe-OH Structure
L-Homophe-OH Chemical Properties
Melting point >300 °C(lit.)
alpha 45 º (C=1, 3N HCl 19 ºC)
Boiling point 311.75°C (rough estimate)
density 1.1248 (rough estimate)
refractive index 44 ° (C=1, 3mol/L HCl)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in dilute aqueous acid.
form Solid
pka2.32±0.10(Predicted)
color White to Off-White
InChIInChI=1/C10H13NO2/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/s3
InChIKeyJTTHKOPSMAVJFE-VIFPVBQESA-N
SMILESC(O)(=O)[C@H](CCC1=CC=CC=C1)N |&1:3,r|
CAS DataBase Reference943-73-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
HS Code 29224999
MSDS Information
ProviderLanguage
(S)-alpha-Amino-benzenebutanoic acid English
SigmaAldrich English
ACROS English
L-Homophe-OH Usage And Synthesis
DescriptionL-Homophenylalanine is an amino acid derivative. It has been extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor: enalapril, delapril, quinapril and ramipril, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). It acts as an anti-tumor reagent.
ReferencesHwang, J. Y., et al. "Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway." Biotechnology & Bioengineering 102.5(2009):1323-9.
Ahmad, A. L., P. C. Oh, and S. R. Abd Shukor. "Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor."Biotechnology Advances 27.3(2009):286-296.
https://www.alfa.com/en/catalog/H27295/
ApplicationL-homophenylalanine is used almost exclusively as single stereoisomer in pharmaceutical drug production. L-homophenylalanine as a common building block, due to the presence of L-homophenylalanine moiety as the central pharmacophore unit. L-homophenylalanine is also an important chiral intermediate to synthesize a variety of novel pharmaceuticals including β-lactam antibiotics, acetylcholinesterase inhibitor and neutral endopeptidace (NEP) inhibitor which retained their status as major contributors to human health preservation. L-homophenylalanine acts as a precursor for the synthesis of NEP inhibitors, which complements the effects of ACE inhibitors when used simultaneously, potentiates the outcome in the management of hypertension and congestive heart failure[1].
Chemical PropertiesWhite Solid
UsesAntitumor agent.
UsesL-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.
DefinitionChEBI: A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain.
Production MethodsAsymmetric reduction of prochiral ketone remains one of the most investigated methods to date for production of chiral L-homophenylalanine. One of the most established method for synthesizing L-homophenylalanine on a laboratory scale was carried out via enzyme-catalyzed asymmetric synthesis of keto acids. In this method, prochiral ketone was converted via reductive amination to enantiopure products with bulky side chains by addition of biocatalysts such as L-homophenylalanine dehydrogena. in the presence of cofactor. L-phenylalanine dehydrogenase is by and large preferred as it has mainly a catabolic function and accepts a wide variety of keto acids as substrates hence it is generally employed in the synthesis of L-homophenylalanine which carries very bulky side chains[1].
References[1] Ahmad A, et al. Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor. Biotechnology Advances, 2009; 27: 286-296.
Tag:L-Homophe-OH(943-73-7) Related Product Information
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