| Company Name: |
ShangHai Anpel Co, Ltd.
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| Tel: |
18501792038 18502138905 |
| Email: |
shanpel@anpel.com.cn |
| Products Intro: |
Product Name:γ-Amanitin
CAS:21150-23-2
Purity:10ppm Package:10mg/L于水，1ml
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:γ-Amanitin
CAS:21150-23-2
Package:100mg;250mg;500mg Remarks: 试剂级
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| Company Name: |
guoyungurui
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| Tel: |
18162595016; 18162595016 |
| Email: |
3287908757@qq.com |
| Products Intro: |
Product Name:Dimethylacetamide Impurity 4 (Dimethylacetamide EP Impurity D)
CAS:21150-23-2
Purity:95%+HPLC Package:10mg;25mg;50mg;100mg;200mg
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| | gamma-amanitin Basic information |
| Product Name: | gamma-amanitin | | Synonyms: | Cyclo[L-Asn-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-];GAMMA-AMANITIN;α-Amanitin, 3-[(4S)-4-hydroxy-L-isoleucine]-;γ-Amanitin;Dimethylacetamide Impurity 4 (Dimethylacetamide EP Impurity D);gamma-Amanitin, RNA polymerase II inhibitor | | CAS: | 21150-23-2 | | MF: | C39H54N10O13S | | MW: | 902.98 | | EINECS: | | | Product Categories: | | | Mol File: | 21150-23-2.mol |  |
| | gamma-amanitin Chemical Properties |
| Boiling point | 1566.5±65.0 °C(Predicted) | | density | 1.1527 (rough estimate) | | refractive index | 1.7400 (estimate) | | form | White to off-white powder. | | pka | 9.63±0.70(Predicted) | | color | Colorless to light yellow |
| | gamma-amanitin Usage And Synthesis |
| Uses | γ-Amanitin an ADC cytotoxin and isolated from the?mushroom. γ-Amanitin inhibits?RNA polymerase II and disrupts synthesis of?mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells[1][2][3]. | | in vivo | γ-amanitin (i.p.) is classified as a neutral amanitin with an LD50 in mice ranging from 0.2 to 0.5 mg/kg[3].
| | IC 50 | Traditional Cytotoxic Agents | | References | [1] He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. DOI:10.1016/j.biologicals.2017.06.008
[2] Gong M, et al. Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3. Food Chem Toxicol. 2024 Jun;188:114665. DOI:10.1016/j.fct.2024.114665
[3] Garcia J, et al. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food Chem Toxicol. 2015 Dec;86:41-55. DOI:10.1016/j.fct.2015.09.008 |
| | gamma-amanitin Preparation Products And Raw materials |
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