- 2-Fluoro-5-nitropyridine
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- $5.00 / 1KG
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2024-04-08
- CAS:456-24-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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| | 2-Fluoro-5-nitropyridine Basic information |
| | 2-Fluoro-5-nitropyridine Chemical Properties |
| Melting point | 142-144 C | | Boiling point | 86-87℃/7mm lit. | | density | 4,64g/cm | | refractive index | 1.5250 | | storage temp. | Inert atmosphere,Room Temperature | | form | Liquid | | pka | -4.47±0.10(Predicted) | | color | Colorless to pale yellow | | Water Solubility | Slightly soluble in water. | | Sensitive | Moisture Sensitive | | CAS DataBase Reference | 456-24-6(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-22 | | Safety Statements | 36 | | RIDADR | UN 1549 | | HS Code | 2933399990 |
| | 2-Fluoro-5-nitropyridine Usage And Synthesis |
| Uses | 2-Fluoro-5-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Uses | It is used in the preparation of nitropyridines by nitration of pyridines with nitric acid. | | Synthesis | 
Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 ??C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 ?á 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%). |
| | 2-Fluoro-5-nitropyridine Preparation Products And Raw materials |
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