| 中文名称 | 8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT |
|---|---|
| 中文同义词 | |
| 英文名称 | 8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT |
| 英文同义词 | 8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-8-cpt-camps),sodi;SP-8-PCPT-CAMPS;8-(4-Chlorophenylthio)-adenosine-3'',5''-cyclic monophosphothioate sodium sal;8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT;ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-(4-CHLOROPHENYLTHIO)-, SP-ISOMER, SODIUM SALT;SP-8-CPT-CAMPS SODIUM SALT;SP-8-PCPT-CAMPS, NA;Sp-8-CPT-cAMPS |
| CAS号 | 129693-13-6 |
| 分子式 | C16H14ClN5NaO5PS2 |
| 分子量 | 509.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 129693-13-6.mol |
| 结构式 |  |
8-(4-CHLOROPHENYLTHIO) ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT 性质
| 储存条件 | −70°C |
|---|---|
| 溶解度 | H2O:>1 mg/mL |
| 形态 | 固体 |
Sp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 依赖性蛋白激酶 A PKA I 和 PKA II 的有效和选择性的激活剂。Sp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。
PKA
Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells.
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells.
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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