UVI 3003
| 中文名称 | UVI 3003 |
|---|---|
| 中文同义词 | 3-[4-羟基-3-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(戊基氧基)-2-萘]苯基]-2-丙酸;化合物UVI 3003;UVI 3003,RXR拮抗剂 |
| 英文名称 | 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoicacid |
| 英文同义词 | UVI 3003;3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoicacid;UVI 3003;UVI-3003;UVI3003;2-Propenoic acid, 3-[4-hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-;3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoicacid ISO 9001：2015 REACH;3-(4-Hydroxy-3-(5,5,8,8-tetramethyl-3-(pentyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl)acrylic acid;UVI-3003,UVI3003,Retinoid X receptors,Autophagy,RAR/RXR,Inhibitor,Retinoic acid receptors,inhibit,UVI 3003 |
| CAS号 | 847239-17-2 |
| 分子式 | C28H36O4 |
| 分子量 | 436.58 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 847239-17-2.mol |
| 结构式 |  |
UVI 3003 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | DMF：25mg/mL； DMSO：15mg/mL；乙醇：20mg/mL |
| 形态 | 结晶固体 |
UVI 3003 是一种高度选择性的 retinoid X receptor (RXR) 抑制剂，在 Cos7 细胞中，抑制非洲爪蟾蜍和人 RXRα 的活性，IC50 值分别为 0.22 和 0.24 μM。
IC50: 0.22 μM (Xenopus RXRα, in Cos7 cells), 0.24 μM (Human RXRα, in Cos7 cells)
UVI3003 inhibits the activity of xenopus and human RXRα, with IC 50 s of 0.22 and 0.24 μM, respectively. UVI3003 fully activates xPPARγ with an EC 50 of 12.6 μM, and is almost completely inactive on hPPARγ and mPPARγ. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression.
安全信息
| 海关编码 | 2918999090 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-107500 | UVI 3003 | 1 mg | 545元 | |
| 2024/01/25 | HY-107500 | UVI 3003 UVI 3003 | 847239-17-2 | 5mg | 1200元 |