AS 1269574
| 中文名称 | AS 1269574 |
|---|---|
| 中文同义词 | 化合物AS 1269574;2-((2-(4-溴苯基)-6-甲基嘧啶-4-基)氨基)乙醇;AS 1269574,GPR119受体激动剂 |
| 英文名称 | AS 1269574 |
| 英文同义词 | AS 1269574;2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol;2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol;AS-1269574 (AS1269574);AS126957;2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol;Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-;TRP Channel,G Protein-Coupled Receptor 119,secretion,Inhibitor,type,AS1269574,cation,diabetes,insulin,inhibit,Transient receptor potential channels,glucose,GPR119,channels,AS-1269574 |
| CAS号 | 330981-72-1 |
| 分子式 | C13H14BrN3O |
| 分子量 | 308.17 |
| EINECS号 | |
| 相关类别 | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 330981-72-1.mol |
| 结构式 |  |
AS 1269574 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 乙醇溶液 |
AS1269574 是一种有效的，具有口服活性的 GPR119 激动剂，在表达人 GPR119 的 HEK293 细胞中 EC50 为 2.5 μM。AS1269574 激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1 (GLP-1) 分泌。AS1269574 仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。AS1269574 对 2 型糖尿病研究具有潜力。
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TRPA1
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GPR119
|
AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC 0-2h ) of administration.
| Animal Model: | Eight-week-old ICR mice |
| Dosage: | 100 mg/kg |
| Administration: | P.o. |
| Result: | Sgnificantly reduced the blood glucose AUC after 2 h (AUC 0-2h ) of administration. Similarly, plasma insulin AUC 0-2h was significantly higher in the mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-107535 | AS 1269574 AS1269574 | 330981-72-1 | 10mg | 1300元 |
| 2024/04/30 | HY-107535 | AS 1269574 AS1269574 | 330981-72-1 | 50mg | 4000元 |