AX 20017
中文名称 | AX 20017 |
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中文同义词 | 2-(环丙烷甲酰氨基)-4,5,6,7-四氢苯并[B]噻吩-3-甲酰胺;化合物AX20017 |
英文名称 | AX 20017 |
英文同义词 | AX 20017;PknG Inhibitor;2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide;AX-20017; AX 20017;Benzo[b]thiophene-3-carboxamide, 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-;AX 20017,AX20017,Inhibitor,Bacterial,inhibit,AX-20017 |
CAS号 | 329221-38-7 |
分子式 | C13H16N2O2S |
分子量 | 264.34 |
EINECS号 | |
相关类别 | 抑制剂 |
Mol文件 | 329221-38-7.mol |
结构式 |
AX 20017 性质
储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
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溶解度 | 二甲基亚砜:≥32mg/mL(121.06mM) |
IC50: 0.39 μM (PknG)
The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-14987 | AX 20017 AX20017 | 329221-38-7 | 5mg | 500元 |
2024/01/25 | HY-14987 | AX 20017 AX20017 | 329221-38-7 | 10mg | 700元 |