PU-02; PU02
| 中文名称 | PU-02; PU02 |
|---|---|
| 中文同义词 | 6-((萘-1-基甲基)硫基)-7H-嘌呤;化合物PU-02;6-[(1-萘基甲基)硫基]-9H-嘌呤;PU 02,5-HT3受体的负变构调节剂 |
| 英文名称 | 6-[(1-NaphthalenylMethyl)thio]-9H-purine |
| 英文同义词 | 6-[(1-NaphthalenylMethyl)thio]-9H-purine;PU 02;6-((Naphthalen-1-ylmethyl)thio)-7H-purine;6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine;PU-02; PU02;9H-Purine, 6-[(1-naphthalenylmethyl)thio]-;5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit |
| CAS号 | 313984-77-9 |
| 分子式 | C16H12N4S |
| 分子量 | 292.36 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 313984-77-9.mol |
| 结构式 |  |
PU-02; PU02 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末 |
|
5-HT 3A Receptor 0.36 μM (IC 50 ) |
5-HT 3 AB 0.73 μM (IC 50 ) |
PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC
50
=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment.
PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells.
PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected.
PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity.
Apoptosis Analysis
| Cell Line: | HepG2 cells. |
| Concentration: | 6.26, 12.5, 25, 50 μM. |
| Incubation Time: | 6, 12, 24, 36 h. |
| Result: | Induced mitochondria-dependent apoptosis. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-103118 | PU02 | 5 mg | 700元 | |
| 2024/04/30 | HY-103118 | PU-02; PU02 PU02 | 313984-77-9 | 10mM * 1mLin DMSO | 770元 |