L-2,4-二氨基丁酸氢溴酸盐
中文名称 | L-2,4-二氨基丁酸氢溴酸盐 |
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中文同义词 | L-2,4-二氨基丁酸氢溴酸盐;L-2,4-二氨基丁酸氨溴酸盐;L-2,4-二氨基丁酸;L-2,4-二氨基丁酸氢溴酸盐· HCL |
英文名称 | L-DAB HBR |
英文同义词 | L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE;L-DAB HBR;L-DAB HYDROBROMIDE;L-2,4-Diaminobutanoate;H-DabHBr;(S)-2,4-Diaminobutyric acid;L-DABA;L-2,4-Diaminobutyric acid hydrobromine |
CAS号 | 1758-80-1 |
分子式 | C4H10N2O2 |
分子量 | 118.13 |
EINECS号 | |
相关类别 | 非天然氨基酸极其衍生物;化学生物学;其他生化试剂;Unusual Amino Acids;Amino hydrochloride |
Mol文件 | 1758-80-1.mol |
结构式 |
L-2,4-二氨基丁酸氢溴酸盐 性质
熔点 | 216-218 °C |
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沸点 | 321.0±32.0 °C(Predicted) |
密度 | 1.218±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C(protect from light) |
形态 | 粉末 |
酸度系数(pKa) | 2.00±0.10(Predicted) |
颜色 | 白色至米白色 |
CAS 数据库 | 1758-80-1(CAS DataBase Reference) |
Human Endogenous Metabolite
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The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.
Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro .
安全信息
海关编码 | 2922498590 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101414 | L-2,4-二氨基丁酸氢溴酸盐 L-DABA | 1758-80-1 | 100mg | 500元 |