硫酸碘苄胍 EP标准品
| 中文名称 | 硫酸碘苄胍 EP标准品 |
|---|---|
| 中文同义词 | 硫酸碘苄胍 EP标准品;IOBENGUANE HEMISULFATE;1-(3-碘苄基)胍半硫酸盐;3-碘苄胍硫酸盐;萘伐莫司他杂质14 |
| 英文名称 | 3-IODOBENZYL-GUANIDINE HEMISULFATE |
| 英文同义词 | M-IBG;MIBG HEMISULFATE SALT;M-IODOBENZYLGUANIDINE HEMISULFATE SALT;M-IODOBENZYLGUANIDINE 1/2H2SO4;Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1);meta-Iodobenzylguanidine hemisulfate;MIBG hemisulfate;m-iodobenzylguanidine sulfate |
| CAS号 | 87862-25-7 |
| 分子式 | C16H22I2N6O4S |
| 分子量 | 648.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 87862-25-7.mol |
| 结构式 |  |
硫酸碘苄胍 EP标准品 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：2mg/mL； DMSO:PBS (pH 7.2) (1:4)：0.2 mg/mL |
| 形态 | 结晶固体 |
Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines.
Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range.
Cell Proliferation Assay
| Cell Line: | 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells |
| Concentration: | 2, 20μg/ml |
| Incubation Time: | 72 hours |
| Result: | Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth. |
Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity.
The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed.
Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg.
| Animal Model: | DBA/2 (L1210)) mice |
| Dosage: | i.p.; daily on days 3-6 |
| Administration: | 20 mg/kg |
| Result: | Considerable prolongation of survival and some cures were obtained. |
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 2909309090 |
| 提供商 | 语言 |
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英文
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