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疟疾平

疟疾平 更多供应商
公司名称: 北京百灵威科技有限公司  
联系电话: 400-666-7788 010-82848833
产品介绍: 中文名称:二盐酸奎吖因水合物
英文名称:Quinacrine Dihydrochloride Hydrate
CAS:69-05-6
纯度:98.0%(LC&T) 包装信息:25G 备注:化学试剂、精细化学品、医药中间体、材料中间体
公司名称: 上海迈瑞尔化学技术有限公司  
联系电话: 400-660-8290 21-61259100
产品介绍: 中文名称:二盐酸奎吖因水合物
英文名称:Quinacrine Dihydrochloride Hydrate
CAS:69-05-6
包装信息:25g 备注:Q0056
公司名称: 梯希爱(上海)化成工业发展有限公司  
联系电话: 021-67121386 / 800-988-0390
产品介绍: 中文名称:二盐酸奎吖因水合物
英文名称:Quinacrine Dihydrochloride Hydrate
CAS:69-05-6
包装信息:25G 备注:试剂级
公司名称: 北京华威锐科化工有限公司  
联系电话: 18516978288 0757-86329057
产品介绍: 中文名称:喹吖因二盐酸盐
英文名称:Quinacrine dihydrochloride
CAS:69-05-6
纯度:98.00% 包装信息:5g
公司名称: 萨恩化学技术(上海)有限公司(安徽泽升科技有限公司)  
联系电话: 400-005-6266 021-58432009
产品介绍: 英文名称:Quinacrine Dihydrochloride Hydrate
CAS:69-05-6
包装信息:25G 备注:详见进口目录
最新发布供应信息
疟疾平_广州贝尔卡生物科技有限公司
2021/10/22 11:41:02
疟疾平
生物活性靶点体外研究体内研究 MSDS 用途与合成方法 疟疾平价格(试剂级) 上下游产品信息
中文名称:疟疾平
中文同义词:疟疾平;二盐酸喹吖因;喹吖因二盐酸;阿的平 二盐酸盐;二盐酸阿的平;二盐酸喹丫因;疟涤平;盐酸阿的平
英文名称:QUINACRINE DIHYDROCHLORIDE
英文同义词:6-CHLORO-9-(4-DIETHYLAMINO-1-METHYL-BUTYLAMINO)-2-METHOXYACRIDINE DIHYDROCHLORIDE;6-CHLORO-9-(4-DIETHYLAMINO-1-METHYL-N-BUTYL)AMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE;ERION HYDROCHLORIDE;DL-QUINACRINE HYDROCHLORIDE;CHINACRIN HYDROCHLORIDE;CHEMIOCHIN HYDROCHLORIDE;ARICHIN HYDROCHLORIDE;ATABRINE
CAS号:69-05-6
分子式:C23H32Cl3N3O
分子量:472.88
EINECS号:200-700-8
相关类别:小分子抑制剂;细胞信号和神经生物学;细胞生物学
Mol文件:69-05-6.mol
疟疾平
疟疾平 性质
熔点 249-251℃ (Decomposition)
密度 1.2962 (rough estimate)
折射率 1.6300 (estimate)
储存条件 +15C to +30C
形态Yellow solid
酸度系数(pKa)pKa -6.3(H2O t undefined I not reported but low) (Uncertain)
PH值3.0~5.0 (20g/l, 25℃)
Merck 14,8044
BRN 4834013
稳定性Stable. Incompatible with strong oxidizing agents.
EPA化学物质信息Quinacrine hydrochloride (69-05-6)
疟疾平 用途与合成方法
生物活性Quinacrine 2HCl是具有多种作用的亲脂性阳离子药物,通常用作抗原生动物剂。Quinacrine是有效的phospholipase A2抑制剂。
靶点
TargetValue
PLA2
()
体外研究

Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .

Cell Viability Assay

Cell Line: SGC-7901 cells
Concentration: 0, 5, 10, 15, and 20 μM
Incubation Time: 24 hours
Result: Cell viability was inhibited in a dose-dependent manner, and the mean IC 50 value is 16.18 μM.

Apoptosis Analysis

Cell Line: SGC-7901 cells
Concentration: 7.5 and 15 μM
Incubation Time: 24 hours
Result: The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.

Western Blot Analysis

Cell Line: SGC-7901 cells
Concentration: 15 μM
Incubation Time: 24 hours
Result: The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
体内研究

Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.

Animal Model: Female SCID mice with acute myeloid leukemia (AML)-PS model
Dosage: 100 mg/kg
Administration: Administered by oral gavage (po); three times a week for two consecutive weeks
Result: In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
类别有毒物质
毒性分级中毒
急性毒性口服- 大鼠 LD50: 660 毫克/ 公斤; 口服- 小鼠 LD50: 557 毫克/ 公斤
可燃性危险特性可燃;火场释放有毒氮氧化物, 氯化物烟雾
储运特性库房低温, 通风, 干燥
灭火剂水, 二氧化碳, 泡沫, 沙土
安全信息
危险品标志 Xn
危险类别码 22-36/37/38
安全说明 36/37/39
WGK Germany 3
RTECS号AR7875000
毒性LD50 oral in rabbit: 433mg/kg
疟疾平 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2018/06/12Q0056二盐酸奎吖因水合物
Quinacrine Dihydrochloride  Hydrate
69-05-625G920元
2011/08/2330161680喹吖因二盐酸盐(阴凉)69-05-610g228.2元
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