142873-41-4
| 中文名称 | 142873-41-4 |
|---|---|
| 中文同义词 | 脂质过氧化抑制剂1;化合物 T10166 |
| 英文名称 | 5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]- |
| 英文同义词 | 5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-;Lipid peroxidation inhibitor 1 |
| CAS号 | 142873-41-4 |
| 分子式 | C24H32N2O |
| 分子量 | 364.52368 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 142873-41-4.mol |
| 结构式 |  |
142873-41-4 性质
| 沸点 | 520.4±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.090±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.09±0.10(Predicted) |
Lipid peroxidation inhibitor 1 是一种脂质过氧化 (lipid peroxidation) 抑制剂，其 IC50 值为 0.07 μM。
IC50: 0.07μM (lipid peroxidation)
Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC 50 of 0.07 μM.
Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective.
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