1684386-71-7
| 中文名称 | 1684386-71-7 |
|---|---|
| 中文同义词 | N-[4-(2-氯-5-甲基-4-嘧啶基)苯基]-N-[[4-[[(2,2-二氟乙酰基)氨基]甲基]苯基]甲基]-2,4 -二羟基-苯甲酰胺;化合物VER-246608 |
| 英文名称 | VER-246608 |
| 英文同义词 | VER-246608;N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxybenzamide;Benzamide, N-[4-(2-chloro-5-methyl-4-pyrimidinyl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxy-;VAR-246608;Inhibitor,VER 246608,PDHK,VER246608,VER-246608,Pyruvate dehydrogenase kinase,inhibit,PDH kinase;N-(4-(2-Chloro-5-methylpyrimidin-4-yl)phenyl)-N-(4-((2,2-difluoroacetamido)methyl)benzyl)-2,4-dihydroxybenzamide |
| CAS号 | 1684386-71-7 |
| 分子式 | C28H23ClF2N4O4 |
| 分子量 | 552.96 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1684386-71-7.mol |
| 结构式 |  |
1684386-71-7 性质
| 沸点 | 830.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.414±0.06 g/cm3(Predicted) |
| 溶解度 | DMF:2.0(最大浓度 mg/mL);3.62(最大浓度 mM) DMSO:2.0(最大浓度 mg/mL);3.62(最大浓度 mM) DMSO:PBS ( pH 7.2) (1:1):0.5(最大浓度 mg/mL);0.9(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.61±0.35(Predicted) |
IC50: 35 nM (PDK-1), 40 nM (PDK-3), 84 nM (PDK-2), 91 nM (PDK-4)
VER-246608 is a novel pan-isoform ATP competitive inhibitor of PDK. VER-246608 demonstrates similar potency across all four PDK isoforms in a DELFIA-based enzyme functional assay in the sub 100 nM range. In terms of cellular biomarker modulation, VER-246608 suppresses the phosphorylation of the Ser 293 residue of E1α (phosphorylated by all four PDK isozymes) with IC 50 values of 266 nM. Treatment of PC-3 cells with 9 μM and 27 μM VER-246608 results in a 21% and 42% reduction, respectively, in media L-lactate levels following a 1 h incubation. VER-246608 also decreases D-glucose consumption at the same concentrations that result in reduced L-lactate production. An approximately 50% reduction in spheroid volume is achieved at concentrations of 10 μM and above, suggesting an increase in VER-246608 potency compared to monolayer growth.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12492 | 1684386-71-7 VER-246608 | 1684386-71-7 | 1mg | 636元 |
| 2024/04/30 | HY-12492 | 1684386-71-7 VER-246608 | 1684386-71-7 | 5mg | 1400元 |