消旋型二氟甲基腈盐酸盐
| 中文名称 | 消旋型二氟甲基腈盐酸盐 |
|---|---|
| 中文同义词 | DL-Α-二氟甲基鸟氨酸盐酸盐;依氟鸟氨酸碱盐酸盐;消旋型二氟甲基腈盐酸盐;依氟鸟氨酸碱(消旋体);二氟甲基鸟氨酸;DL-ALPHA-二氟甲基鸟氨酸盐酸盐;依氟鸟氨酸碱;依氟乌氨酸 |
| 英文名称 | DFMO |
| 英文同义词 | 96020-91-6 (Mono-hydrochloride, monohydrate);alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid;Brn 2250529;Ccris 3295;DL-2-(Difluoromethyl)-ornithinehydrochloride;DL-α-Difluoromethylornithine hydrochloride hydrate,2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate;DIFLUOROMETHYLORNITHINE(RG);α-Difluoromethyl-DL-ornithine |
| CAS号 | 70052-12-9 |
| 分子式 | C6H12F2N2O2 |
| 分子量 | 182.17 |
| EINECS号 | |
| 相关类别 | 氨基酸衍生化合物;脱毛剂;进口原料;facial hair remover |
| Mol文件 | 70052-12-9.mol |
| 结构式 |  |
消旋型二氟甲基腈盐酸盐 性质
| 熔点 | 138 °C |
|---|---|
| 沸点 | 347.0±42.0 °C(Predicted) |
| 密度 | 1.1800 (estimate) |
| 储存条件 | Store at 0°C |
| 溶解度 | H2O: >10 mg/mL, 可溶 |
| 酸度系数(pKa) | 1.22±0.44(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色 |
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.
安全信息
| WGK Germany | 3 |
|---|---|
| 毒害物质数据 | 70052-12-9(Hazardous Substances Data) |