甘氨胆酸
| 中文名称 | 甘氨胆酸 |
|---|---|
| 中文同义词 | 甘氨胆酸水合物;甘氨石胆酸;12-三羟基-24-羰基胆烷-24-基)-甘氨酸;甘氨胆酸(标准品);甘氨胆酸(3Α,7Α,12Α-三羟基-5Β-胆甾烷-24-羧酸-24-甘氨酰胺、甘胆酸、N-(3,7,12-三羟基-24-羰基胆烷-24-基)-甘氨酸、甘氨石胆酸);甘胆酸水合物;甘膽酸;N-(3,7,12-三羟基-24-羰基胆烷-24-基)-甘氨酸 |
| 英文名称 | Glycocholic acid |
| 英文同义词 | GLYCOCHOLIC ACID;GLYCOCHOLIC;CHOLYLGLYCINE HYDRATE;Glycine, N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]-;N-((3,5,7,12)-3,7,12-Trihydroxy-24-oxocholan-24-yl)glycine;5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL N-(CARBOXYMETHYL)-AMIDE;5BETA-CHOLANIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL 24-N-(CARBOXYMETHYL)-AMIDE;3a,7a,12a-trihydroxy-5b-cholan-24-oic acid n-(carboxymethyl)amide |
| CAS号 | 475-31-0 |
| 分子式 | C26H43NO6 |
| 分子量 | 465.63 |
| EINECS号 | 207-494-9 |
| 相关类别 | 原料药;医药中间体;小分子抑制剂;植物提取物;胆酸系列;小分子抑制剂，天然产物;医药原料药;碳水化合物;Miscellaneous Natural Products;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API;Inhibitors;对照品;医用原料;医药、农药及染料中间体;中药对照品;医药原料;材料中间体及助剂;聚合;新材料;通用生化试剂-脂类;生物化工 |
| Mol文件 | 475-31-0.mol |
| 结构式 |  |
甘氨胆酸 性质
| 熔点 | 128°C |
|---|---|
| 沸点 | 568.76°C (rough estimate) |
| 密度 | 1.1336 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | Refrigerator |
| 溶解度 | 甲醇：0.1 g/mL，澄清，无色 |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.4(at 25℃) |
| 颜色 | 白色至类白色 |
| 水溶解性 | 329.9mg/L(20 ºC) |
| Merck | 13,4507 |
| 稳定性 | 吸湿性 |
| InChIKey | RFDAIACWWDREDC-NSPZZGDONA-N |
| LogP | 1.650 |
| CAS 数据库 | 475-31-0(CAS DataBase Reference) |
| NIST化学物质信息 | Glycocholic acid(475-31-0) |
|
Human Endogenous Metabolite
|
Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways.
| 提供商 | 语言 |
|---|---|
|
英文
|