374703-78-3
中文名称 | 374703-78-3 |
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中文同义词 | 化合物PKG DRUG G1 |
英文名称 | PKG drug G1 |
英文同义词 | PKG drug G1;4-Imidazolidinone, 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-;PKG drug G 1,PKG drug G-1,PKG drug G1,Inhibitor,inhibit |
CAS号 | 374703-78-3 |
分子式 | C13H11N3OS |
分子量 | 257.31 |
EINECS号 | |
相关类别 | |
Mol文件 | 374703-78-3.mol |
结构式 |
374703-78-3 性质
密度 | 1.45±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | DMF:25mg/mL; DMSO:20mg/mL;乙醇:2mg/mL; PBS (pH 7.2):部分溶解 |
形态 | 结晶固体 |
酸度系数(pKa) | 6.71±0.20(Predicted) |
Target | Value |
PKG Iα
() |
PKG drug G1 induces vasodilation of isolated resistance blood vessels and blood pressure lowering in a mouse model of angiotensin II–induced hypertension. PKG drug G1 efficiently relaxes WT but not knockin (KI) vessels, which is then assessed in a murine model of hypertension. PKG drug G1 lowers blood pressure in hypertensive WT, but not KI, mice in vivo. PKG drug G1 is tested in vivo in healthy mice implanted with telemetric devices that allow blood pressure and heart rate to be constantly monitored. PKG drug G1 or vehicle control is administrated by intraperitoneal injection, and the acute impact on hemodynamics assessed. PKG drug G1 administered at 7.4 mg/kg does not decrease blood pressure, but there is a concomitant reflex tachycardia. When this is repeated using 14.8 mg/kg dose of PKG drug G1, again blood pressure is not altered-but this higher dose induces a potentiated increase in heart rate.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-112197 | PKG drug G1 | 1 mg | 380元 | |
2024/01/25 | HY-112197 | 374703-78-3 PKG drug G1 | 374703-78-3 | 5mg | 1000元 |