氟伏沙明
| 中文名称 | 氟伏沙明 |
|---|---|
| 中文同义词 | 氟提肟氨;(E)-5-甲氧基-4-三氟甲基苯戊酮氧-2-氨乙酰基肟;氟伏沙明;氟伏沙明系列杂质标准品、对照品;氟伏沙明-D3;氟伏沙明F603500;马来酸氟伏沙明杂质D3;氟伏沙明 54739-18-3 |
| 英文名称 | Fluvoxamine |
| 英文同义词 | 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]-pentylidene]amino]oxyethanamine;(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentanal O-(2-aminoethyl)oxime;(E)-ω-Methoxy-4'-(trifluoromethyl)valerophenone O-(2-aminoethyl)oxime;δ-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime;Fluvoxamine See: F603500;Fluvoxamine Also See: F603500;FLUVOXAMINE;(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanoneo-(2-aminoethyl)oxime |
| CAS号 | 54739-18-3 |
| 分子式 | C15H21F3N2O2 |
| 分子量 | 318.33 |
| EINECS号 | 611-193-1 |
| 相关类别 | 神经系统用药;医药原料;杂质对照品;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 54739-18-3.mol |
| 结构式 |  |
氟伏沙明 性质
| 熔点 | 120-122.5°C |
|---|---|
| 沸点 | 370.6±52.0 °C(Predicted) |
| 密度 | 1.16±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 可溶于氯仿（少量）、DMSO（少量）、甲醇（少量） |
| 形态 | 油状 |
| 酸度系数(pKa) | pKa 8.7 (Uncertain) |
| 颜色 | 无色 |
| CAS 数据库 | 54739-18-3(CAS DataBase Reference) |
| NIST化学物质信息 | Fluvoxamine(54739-18-3) |
SSRIs.
Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement.