AURORA INHIBITOR 1
| 中文名称 | AURORA INHIBITOR 1 |
|---|---|
| 中文同义词 | 化合物 T10412 |
| 英文名称 | Aurora inhibitor 1 |
| 英文同义词 | Aurora inhibitor 1;Imidazo[1,2-a]pyrazin-8-amine, N-[3-[[(1,1-dimethylethyl)amino]-2-pyridinylmethyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)- |
| CAS号 | 2227019-45-4 |
| 分子式 | C23H25N9S |
| 分子量 | 459.58 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 2227019-45-4.mol |
| 结构式 |  |
AURORA INHIBITOR 1 性质
| 密度 | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 12.67±0.50(Predicted) |
Aurora inhibitor 1 是一种有效的 Aurora 抑制剂，抑制 Aurora A 和 Aurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。
|
Aurora A 4 nM (IC 50 ) |
Aurora B 13 nM (IC 50 ) |
Aurora inhibitor 1 (Compound 16) exhibits K d values of 0.01 nM for both Aurora A and Aurora B kinase.
Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally.