氯唑西林钠一水合物
氯唑西林钠一水合物 性质
熔点 | 170℃ |
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沸点 | 689℃ |
闪点 | >110°(230°F) |
储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | H2O中可溶50mg/mL |
形态 | 固体 |
颜色 | 白色至橙色再至绿色 |
水溶解性 | Soluble in water |
Merck | 13,2444 |
BRN | 5403885 |
CAS 数据库 | 7081-44-9(CAS DataBase Reference) |
Cloxacillin Sodium是Cloxacillin的钠盐形式,是一种耐青霉素酶,耐酸,半合成的青霉素。
Cloxacillin is an antibiotic useful for the study of a number of bacterial infections.
Cell Viability Assay
Cell Line: | Strains M12 and M60. |
Concentration: | 0.5 μg/mL. |
Incubation Time: | 4-24 h. |
Result: | Significantly reduced the bacterial numbers. |
Cloxacillin sodium (50 mg/kg, Subcutaneously) results a significant antibiotic efficacy against S. aureus .
Animal Model: | Mice. |
Dosage: | 10 mg/kg ( Pharmacological Analysis ). |
Administration: | Given subcutaneously. |
Result: | Reached a maximal concentration in plasma of 8.4 μg/mL at 10 min and had a half-life of approximately 15 min. |
Animal Model: | Mice injected with approximately 2 × 10 6 CFU of bacteria in 0.1 mL saline were aseptically injected into the right thigh muscle. |
Dosage: | 0–500 mg/kg. |
Administration: | Subcutaneously in the nuchal region at 1 h after infection. |
Result: | Resulted in a significant decrease in the number of viable S. aureus measured 18 h thereafter. |
化学性质
白色粉末或结晶性粉末。熔点170℃(分解)。易溶于水,溶于乙醇,微溶于氯仿,有引湿性,微臭,味苦。用途
该品为半合成抗菌素,与苯唑西林的作用特点和用途均极相似,对耐药金葡菌该品有杀菌作用。口服或肌注吸收较好,血浓度比苯唑西林高2倍,主要用于耐药金葡菌所致感染,如败血症、骨髓炎、皮肤软组织感染、心内膜炎、泌尿系统感染及脑膜炎等疗效较好。生产方法
邻甲苯胺经重氮化、置换、氯化、水解、肟化等操作。得到邻氯苯甲肟氯,然后与乙酰乙酸乙酯环合、用五氯化磷氯化,得到3-邻氯苯基-5-甲基-4异噁酰氯,最后与6-APA缩合得到邻氯青霉素碱、加异辛酸钠成盐、即为邻氯青霉素钠。安全信息
危险品标志 | Xn |
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危险类别码 | 36/37/38-42/43 |
安全说明 | 26-36 |
WGK Germany | 2 |
RTECS号 | XH8920000 |
海关编码 | 29411099 |
提供商 | 语言 |
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英文
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