- Picropodophyllotoxin
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- $0.00 / 1KG
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2024-03-18
- CAS:477-47-4
- Min. Order: 1KG
- Purity: 99
- Supply Ability: 10 tons
- (-)PPP
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- $1.00 / 1g
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2019-12-31
- CAS:477-47-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 200kg
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| Product Name: | (-)PPP | | Synonyms: | PICROPODOPHYLLIN;(-)PPP;POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE);NSC 36407, Picropodophyllin, PPP, (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3μ,4μ:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;IGF-1R Inhibitor, PPP;(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;NSC 36407 | | CAS: | 477-47-4 | | MF: | C22H22O8 | | MW: | 414.41 | | EINECS: | | | Product Categories: | Insulin-like Growth Factor-1 Receptor Inhibitor;Picropodophyllin | | Mol File: | 477-47-4.mol |  |
| | (-)PPP Chemical Properties |
| Melting point | 225-227℃ | | alpha | D20 +9.4° (c = 0.7 in chloroform) | | Boiling point | 453.31°C (rough estimate) | | density | 1.370 | | refractive index | 1.4480 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | H2O: soluble | | form | powder | | pka | 13.26±0.40(Predicted) | | color | white | | Sensitive | Light Sensitive | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Codes | Xi,T | | Risk Statements | 36/37/38-68-25-21 | | Safety Statements | 26-36-45-36/37 | | RIDADR | UN 3462 6.1/PG 2 | | WGK Germany | 3 | | RTECS | LV2510000 | | HazardClass | 6.1 | | Toxicity | LD50 intraperitoneal in mouse: 280mg/kg |
| | (-)PPP Usage And Synthesis |
| Description | Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1?Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM.1?Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM.2 Exhibits antiangiogenic activity.3?Picropodophyllotoxin attenuates intimal hyperplasia after vascular injury.4?Active in vivo. | | Uses | Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor | | Uses | Insulin growth factor 1 receptor inhibitor, antineoplastic | | Definition | ChEBI: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents. | | General Description | Poly(2,5-bis(3-sulfonatopropoxy)-1,4-phenylene, disodium salt-alt-1,4-phenylene) (PPP-OPSO3) is a water soluble conjugating polymer that can be used as a donor molecule. It has a poly(p-phenylene) skeleton with each repeating unit having two phenylene groups. It can be used for a variety of optoelectronic applications. | | Biological Activity | Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo . | | Biochem/physiol Actions | Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable. | | storage | Store at +4°C | | References | 1) Girnita et al. (2004), Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth; Cancer Res., 64 236
2) Girnita et al. (2006), The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of iveal melanoma cells; Clin. Cancer Res., 12 1383
3) Menu et al. (2007), Targeting the IGF-1R using picropodophyllin in therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival; Int. J. Cancer, 121 1857
4) Razuvaev et al. (2007), The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling; J. Vasc. Surg., 46 108 |
| | (-)PPP Preparation Products And Raw materials |
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