SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED)
| 中文名称 | SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED) |
|---|---|
| 中文同义词 | |
| 英文名称 | Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-D-Glu-OH |
| 英文同义词 | SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED);SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU;Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH;D-Glutamic acid,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]-;D-Glutamic acid, N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]- (9CI);Suc-F-E-P-I-P-E-Glu-Tyr(OSO3H)-L-DGlu;Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-D-Glu-OH |
| CAS号 | 131791-98-5 |
| 分子式 | C64H88N10O26S |
| 分子量 | 1445.5 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 131791-98-5.mol |
| 结构式 |  |
SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED) 性质
| 密度 | 1.413±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | -15°C |
| 酸度系数(pKa) | -4.17±0.18(Predicted) |
| 序列 | {Suc-Phe}-Glu-Pro-Ile-Pro-Glu-Glu-{Tyr(SO3H)}-Leu-{d-Glu} |
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种 Hirugen 样肽，与 Hirugen 相比，其对凝血酶具有更高的亲和力，KD < 100 nM。Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种抗血栓剂。Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 抑制凝血酶诱导的纤维蛋白凝块形成，IC50 值为 0.087 μM。