一水没食子酸
一水没食子酸 性质
| 熔点 | 252 °C (dec.)(lit.) |
|---|---|
| 密度 | 1.694 |
| 闪点 | 250 °C |
| 储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 溶于乙醇、乙醚、甘油、丙酮，微溶于苯、氯仿、石油醚。 |
| 形态 | 固体 |
| 颜色 | 白色至奶油色 |
| 水溶解性 | 15 g/l (20 ºC) |
| 敏感性 | Hygroscopic |
| Merck | 14,4345 |
| BRN | 2050274 |
| 稳定性 | 感光 |
| InChI | InChI=1S/C7H6O5.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;/h1-2,8-10H,(H,11,12);1H2 |
| InChIKey | IUTKPPDDLYYMBE-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(O)=C(O)C(O)=C1.[H]O[H] |
| CAS 数据库 | 5995-86-8(CAS DataBase Reference) |
一水没食子酸是一种天然多羟基酚类化合物，具有抑制环氧合酶-2 (COX-2) 的自由基清除作用；在制药、食品、轻工诸方面均有广泛用途，也用作分析试剂，还用于制造墨水及照相业。
Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate 是一种天然多羟基酚类化合物，具有抑制环氧合酶-2 (COX-2) 的自由基清除作用。Gallic acid hydrate 具有多种活性，如抗菌、抗氧化、抗菌、抗炎和抗肿瘤活性。|
COX-2
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Human Endogenous Metabolite
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Gallic acid is an antioxidant which can inhibit both COX-2. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis.
The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36-24/25 |
| WGK Germany | 2 |
| RTECS号 | LW7525000 |
| F | 8-9-23 |
| TSCA | Yes |
| 海关编码 | 29182900 |
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