硫坎酮
| 中文名称 | 硫坎酮 |
|---|---|
| 中文同义词 | 1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮;甲硫蒽酮;硫蒽酮;硫坎酮;APE-1抑制剂(LUCANTHONE);甲硫恩酮;1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮 |
| 英文名称 | lucanthone |
| 英文同义词 | lucanthone;1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one;Lycanthone;1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one;Lucanthonum;Lucantona;9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-;Autophagy,inhibit,Lucanthone,Inhibitor |
| CAS号 | 479-50-5 |
| 分子式 | C20H24N2OS |
| 分子量 | 340.48 |
| EINECS号 | 207-532-4 |
| 相关类别 | 细胞生物学试剂;标准品 |
| Mol文件 | 479-50-5.mol |
| 结构式 |  |
硫坎酮 性质
| 熔点 | 64.5°C |
|---|---|
| 沸点 | 512.4±50.0 °C(Predicted) |
| 密度 | 1.0915 (rough estimate) |
| 折射率 | 1.5950 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：25 mg/mL（73.43 mM） |
| 酸度系数(pKa) | 10.00±0.25(Predicted) |
Lucanthone是新型的自噬抑制剂，也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。
APE-1
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.