茚达酮
| 中文名称 | 茚达酮 |
|---|---|
| 中文同义词 | 茚达酮;化合物 T11677 |
| 英文名称 | Irindalone |
| 英文同义词 | Irindalone;1-[2-[4-[(1R)-3β-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1α-yl]-1-piperazinyl]ethyl]-2-imidazolidinone;Lu 21-?098;2-Imidazolidinone, 1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl]- |
| CAS号 | 96478-43-2 |
| 分子式 | C24H29FN4O |
| 分子量 | 408.518 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 96478-43-2.mol |
| 结构式 |  |
茚达酮 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Irindalone 是一种 5-羟色胺 (5-HT2) 拮抗剂。
|
5-HT 2 Receptor
|
Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT 2 receptors and about a 10 times lower affinity for α 1 -adrenoceptors.
Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs.