硫达唑嗪
| 中文名称 | 硫达唑嗪 |
|---|---|
| 中文同义词 | 硫达唑嗪;硫大唑嗪;化合物 T13162 |
| 英文名称 | Tiodazosin |
| 英文同义词 | Tiodazosin;1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[5-(methylthio)-1,3,4-oxadiazol-2-yl]carbonyl]piperazine;BL-5111;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][5-(methylthio)-1,3,4-oxadiazol-2-yl]- |
| CAS号 | 66969-81-1 |
| 分子式 | C18H21N7O4S |
| 分子量 | 431.47 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 66969-81-1.mol |
| 结构式 |  |
硫达唑嗪 性质
| 沸点 | 690.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.50±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6.52±0.50(Predicted) |
Tiodazosin 是一种有效且有竞争性的突触后 α 肾上腺素能受体 (alpha adrenergic receptor) 拮抗剂。
alpha adrenergic receptor
Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA 2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response.