NEVANIMIBE HYDROCHLORIDE
中文名称 | NEVANIMIBE HYDROCHLORIDE |
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中文同义词 | 化合物NEVANIMIBE HYDROCHLORIDE;ATR-101盐酸盐 |
英文名称 | PD 132301-2 |
英文同义词 | PD 132301-2;ATR-101 HCl;Nevanimibe hydrochloride;ATR-101 (PD-132301;Nevanimibe);ATR101 hydrochloride;PD-132301 hydrochloride;cancer,O-acyltransferase,acyl-CoA:cholesterol acyltransferase,acyl-coenzyme,PD-132301,Diglyceride acyltransferase,orally,adrenocortical,Acyltransferase,A:cholesterol,mono- acylglycerol acyltransferase,Nevanimibe hydrochloride,inhibit,PD 132301,Apoptosis,Nevanimibe,ATR 101,PD132301,ATR-101,Diacylglycerol acyltransferase,active,ATR101,Inhibitor |
CAS号 | 133825-81-7 |
分子式 | C27H40ClN3O |
分子量 | 458.09 |
EINECS号 | |
相关类别 | |
Mol文件 | 133825-81-7.mol |
结构式 |
NEVANIMIBE HYDROCHLORIDE 性质
储存条件 | 4°C, away from moisture |
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溶解度 | DMSO:41.67 mg/mL(90.97 mM;需要超声波)| (不溶) |
形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
ACAT1 9 nM (EC 50 ) |
ACAT2 368 nM (EC 50 ) |
Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.
Cell Cytotoxicity Assay
Cell Line: | The H295R and HAC clone 15 (HAC15) human ACC cell lines |
Concentration: | 3 nM-30 μM |
Incubation Time: | 24 hours |
Result: | 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 5mg | 2900元 |
2024/08/19 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 10mM * 1mLin DMSO | 3190元 |