NEVANIMIBE HYDROCHLORIDE
| 中文名称 | NEVANIMIBE HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物NEVANIMIBE HYDROCHLORIDE;ATR-101盐酸盐 |
| 英文名称 | PD 132301-2 |
| 英文同义词 | PD 132301-2;ATR-101 HCl;Nevanimibe hydrochloride;ATR-101 (PD-132301;Nevanimibe);ATR101 hydrochloride;PD-132301 hydrochloride;cancer,O-acyltransferase,acyl-CoA:cholesterol acyltransferase,acyl-coenzyme,PD-132301,Diglyceride acyltransferase,orally,adrenocortical,Acyltransferase,A:cholesterol,mono- acylglycerol acyltransferase,Nevanimibe hydrochloride,inhibit,PD 132301,Apoptosis,Nevanimibe,ATR 101,PD132301,ATR-101,Diacylglycerol acyltransferase,active,ATR101,Inhibitor |
| CAS号 | 133825-81-7 |
| 分子式 | C27H40ClN3O |
| 分子量 | 458.09 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 133825-81-7.mol |
| 结构式 |  |
NEVANIMIBE HYDROCHLORIDE 性质
| 储存条件 | 4°C, away from moisture |
|---|---|
| 溶解度 | DMSO：41.67 mg/mL（90.97 mM；需要超声波）| （不溶） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 (ACAT1) 抑制剂，EC50 为 9 nM。Nevanimibe hydrochloride 抑制 ACAT2，EC50 为 368 nM。Nevanimibe hydrochloride 诱导细胞凋亡 (apoptosis)，并具有抗肾上腺皮质癌的潜力。
|
ACAT1 9 nM (EC 50 ) |
ACAT2 368 nM (EC 50 ) |
Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.
Cell Cytotoxicity Assay
| Cell Line: | The H295R and HAC clone 15 (HAC15) human ACC cell lines |
| Concentration: | 3 nM-30 μM |
| Incubation Time: | 24 hours |
| Result: | 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 5mg | 2900元 |
| 2024/08/19 | HY-100399A | NEVANIMIBE HYDROCHLORIDE Nevanimibe hydrochloride | 133825-81-7 | 10mM * 1mLin DMSO | 3190元 |