NEVANIMIBE HYDROCHLORIDE

NEVANIMIBE HYDROCHLORIDE

中文名称NEVANIMIBE HYDROCHLORIDE
中文同义词化合物NEVANIMIBE HYDROCHLORIDE;ATR-101盐酸盐
英文名称PD 132301-2
英文同义词PD 132301-2;ATR-101 HCl;Nevanimibe hydrochloride;ATR-101 (PD-132301;Nevanimibe);ATR101 hydrochloride;PD-132301 hydrochloride;cancer,O-acyltransferase,acyl-CoA:cholesterol acyltransferase,acyl-coenzyme,PD-132301,Diglyceride acyltransferase,orally,adrenocortical,Acyltransferase,A:cholesterol,mono- acylglycerol acyltransferase,Nevanimibe hydrochloride,inhibit,PD 132301,Apoptosis,Nevanimibe,ATR 101,PD132301,ATR-101,Diacylglycerol acyltransferase,active,ATR101,Inhibitor
CAS号133825-81-7
分子式C27H40ClN3O
分子量458.09
EINECS号
相关类别
Mol文件133825-81-7.mol
结构式NEVANIMIBE HYDROCHLORIDE 结构式

NEVANIMIBE HYDROCHLORIDE 性质

储存条件4°C, away from moisture
溶解度DMSO:41.67 mg/mL(90.97 mM;需要超声波)| (不溶)
形态固体
颜色白色至米白色
水溶解性Water : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

NEVANIMIBE HYDROCHLORIDE 用途与合成方法

Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 (ACAT1) 抑制剂,EC50 为 9 nM。Nevanimibe hydrochloride 抑制 ACAT2,EC50 为 368 nM。Nevanimibe hydrochloride 诱导细胞凋亡 (apoptosis),并具有抗肾上腺皮质癌的潜力。

ACAT1

9 nM (EC 50 )

ACAT2

368 nM (EC 50 )

Coincubation of Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability.

Cell Cytotoxicity Assay

Cell Line: The H295R and HAC clone 15 (HAC15) human ACC cell lines
Concentration: 3 nM-30 μM
Incubation Time: 24 hours
Result: 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/08/19HY-100399ANEVANIMIBE HYDROCHLORIDE
Nevanimibe hydrochloride
133825-81-75mg2900元
2024/08/19HY-100399ANEVANIMIBE HYDROCHLORIDE
Nevanimibe hydrochloride
133825-81-710mM * 1mLin DMSO3190元

NEVANIMIBE HYDROCHLORIDE 上下游产品信息

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