| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:R-82913
CAS:126347-69-1
Package:50mg/RMB 15300;25mg/RMB 11700;100mg/RMB 19500
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R 82913 manufacturers
- R-82913
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- $2180.00 / 50mg
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2025-08-21
- CAS:126347-69-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | R 82913 Basic information |
| Product Name: | R 82913 | | Synonyms: | R 82913;[5S,(+)]-4,5,6,7-Tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione;4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-9-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione;9-Chloro TIBO;TIBO-R82913;TIBO-R-82913;(+)-(S)-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo<4,5,1-jk><1,4>benzodiazepine-2(1H)-thione;9-Cl-Tibo | | CAS: | 126347-69-1 | | MF: | C16H20ClN3S | | MW: | 321.87 | | EINECS: | | | Product Categories: | | | Mol File: | 126347-69-1.mol |  |
| | R 82913 Chemical Properties |
| Boiling point | 429.7±55.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | pka | 11.35±0.40(Predicted) |
| | R 82913 Usage And Synthesis |
| Uses | R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM[1][2]. | | References | [1] White EL, et al. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991 Oct;16(3):257-66. DOI:10.1016/0166-3542(91)90005-c
[2] Larder BA. 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 1992 Dec;36(12):2664-9. DOI:10.1128/AAC.36.12.2664 |
| | R 82913 Preparation Products And Raw materials |
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