三七素
| 中文名称 | 三七素 |
|---|---|
| 中文同义词 | 3-[(羧基羰基)氨基]-L-丙氨酸;3-N-草酰-L-2,3-二氨基丙酸;L-三七素;Β-N-OXALYLAMINO-L-ALANINE 三七素;三七素(3-N-草酰-L-2,3-二氨基丙酸);三七素(3-N-草酰-L-2;山黎豆素;田七素 |
| 英文名称 | 3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID |
| 英文同义词 | 3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID;BETA-N-OXALYL-ALPHA,BETA-DIAMINOPROPIONICACID;BETA-N-OXALAMINO-L-ALANINE;BETA-N-OXYALYLAMINE-L-ALANINE;(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid;Dencichin;ODAP;β-L-ODAP |
| CAS号 | 5302-45-4 |
| 分子式 | C5H8N2O5 |
| 分子量 | 176.13 |
| EINECS号 | |
| 相关类别 | 植物提取物;对照品;标准品;中药对照品;分析试剂标准品;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;标准品，对照品 |
| Mol文件 | 5302-45-4.mol |
| 结构式 |  |
三七素 性质
| 密度 | 1.596±0.06 g/cm3 (20 ºC 760 Torr) |
|---|---|
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 0.1MHCl：可溶性2mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 1.99±0.10(Predicted) |
| 颜色 | 白色至米色 |
| 旋光性 (optical activity) | [α]/D -17 to -23°, c = 0.5 (Solvent: 4N HCl) |
PHD-2
Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN).
Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models.