- Cyclopiazonic acid
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- $83.00 / 1mg
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2024-11-19
- CAS:18172-33-3
- Min. Order:
- Purity: 99.27%
- Supply Ability: 10g
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| CYCLOPIAZONIC ACID Basic information |
Product Name: | CYCLOPIAZONIC ACID | Synonyms: | -Cyclopiazonic acid / CPA;Cyclopiazonic acid from Penicillium grisefulvum;Cyclopiazonic acid (CPA);Cyclopiazonic acid, FroM PenicilliuM griseofulvuM;(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one;(6a-alpha,11a,11b-alpha)--10-acetyl-7-dimethyl-11-hydroxy-;9h-pyrrolo(1’,2’:2,3)isoindolo(4,5,6-cd)indol-9-one,2,6,6a,7,11a,11b-hexahydro;(6AA, 10Z, 11AB, 11BA)-6A,7,11A,11B-TETRAHYDRO-10-(1-HYDROXYETHYLIDENE)-7,7- DIMETHYL-6H-PYRROLO [1',2':2,3]ISOINDOLO [4,5,6-CD]INDOLE-9,11 (2H,10H)-DIONE | CAS: | 18172-33-3 | MF: | C20H20N2O3 | MW: | 336.38 | EINECS: | | Product Categories: | Signalling;Calcium signaling;antibiotic | Mol File: | 18172-33-3.mol |  |
| CYCLOPIAZONIC ACID Chemical Properties |
Melting point | 245-246°C | Boiling point | 472.86°C (rough estimate) | density | 1.2171 (rough estimate) | refractive index | 1.5700 (estimate) | storage temp. | -20°C | solubility | DMSO: soluble | form | powder | pka | 4.50±1.00(Predicted) | color | white to off-white | Water Solubility | Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water. | EPA Substance Registry System | Cyclopiazonic acid (18172-33-3) |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 36/37/39-45 | RIDADR | UN 2811 6.1/PG 2 | WGK Germany | 3 | RTECS | UY8587000 | HazardClass | 6.1(a) | PackingGroup | II | HS Code | 29337900 | Hazardous Substances Data | 18172-33-3(Hazardous Substances Data) | Toxicity | chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl, |
| CYCLOPIAZONIC ACID Usage And Synthesis |
Description | Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 μM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg. | Chemical Properties | off-white powder or crystals | Uses | Cyclopiazonic acid from?Penicillium cyclopium has been used:
- as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
- as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)
- as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
- as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+?during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA
| Uses | The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase. | Uses | Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3. | General Description | Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species. | Biological Activity | Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase. | Biochem/physiol Actions | Inhibits the sarcoplasmic reticulum Ca2+-pump. | storage | -20°C |
| CYCLOPIAZONIC ACID Preparation Products And Raw materials |
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