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| | methyl 2-chloropyrimidine-4-carboxylate Basic information | | Uses Synthesis |
| Product Name: | methyl 2-chloropyrimidine-4-carboxylate | | Synonyms: | methyl 2-chloropyrimidine-4-carboxylate;2-Chloro-4-(methoxycarbonyl)pyrimidine;4-PyriMidinecarboxylic acid, 2-chloro-, Methyl ester;4-PyriMidinecarboxylic ac...;2-Chloro-pyriMidine-4-carboxylic acid Methyl ester;2-Chloro-4-(methoxycarbonyl)pyrimidine, 2-Chloro-4-(methoxycarbonyl)-1,3-diazine;2-Chloro-pyrimidin-4-carboxylic acid methyl ester;2-chloro-4-Pyrimidinecarboxylic acid methyl ester | | CAS: | 149849-94-5 | | MF: | C6H5ClN2O2 | | MW: | 172.57 | | EINECS: | 687-723-0 | | Product Categories: | Heterocycle-Pyrimidine series | | Mol File: | 149849-94-5.mol |  |
| | methyl 2-chloropyrimidine-4-carboxylate Chemical Properties |
| Boiling point | 304.3±15.0 °C(Predicted) | | density | 1.372±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | -3.78±0.20(Predicted) |
| | methyl 2-chloropyrimidine-4-carboxylate Usage And Synthesis |
| Uses | Methyl 2-chloropyrimidine-4-carboxylate is an organic ester, which can be used as an intermediate in pharmaceutical synthesis for experimental research and pharmaceutical synthesis. | | Synthesis | Synthesis of methyl 2-chloropyrimidine-4-carboxylate: 2-chloropyrimidine-4-carboxylic acid (4.76 g, 30 mmol) was dissolved in dichloromethane (30 mL) and dimethylformamide (0.3 mL), to which was added Slowly add oxalyl chloride (5.72g, 45mmol) dropwise, stir at room temperature for 2 hours, Chemicalbook, after concentrating to an appropriate volume, add dropwise to anhydrous methanol (50mL) placed under ice bath conditions, after the dropwise addition, the reaction is transferred to The reaction was carried out at room temperature for 2 hours, and concentrated under reduced pressure to obtain (5.17 g, yield 100%). |
| | methyl 2-chloropyrimidine-4-carboxylate Preparation Products And Raw materials |
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