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| Product Name: | DCPIB | | Synonyms: | DCPIB;4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID;4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID;Butanoic acid, 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-;Cl-Channels,Chloride Channel,cardiomyocytes,DCPIB,ischemia,COS-7,KcsA,Potassium Channel,CPAE cell,Inhibitor,inhibit,swelling,rMCAO;4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid | | CAS: | 82749-70-0 | | MF: | C22H28Cl2O4 | | MW: | 427.36 | | EINECS: | 604-604-1 | | Product Categories: | Chloride channel | | Mol File: | 82749-70-0.mol |  |
| | DCPIB Chemical Properties |
| Boiling point | 593.8±50.0 °C(Predicted) | | density | 1.262±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO | | pka | 4.53±0.10(Predicted) | | form | solid | | color | White |
| | DCPIB Usage And Synthesis |
| Uses | DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells. | | Definition | ChEBI: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid is a member of indanones. | | Biological Activity | Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro . | | storage | Store at +4°C |
| | DCPIB Preparation Products And Raw materials |
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