4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
| 中文名称 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 |
|---|---|
| 中文同义词 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸;ONO-AE3-208中间体;ONO-AE3-208,性EP4拮抗剂 |
| 英文名称 | ONO-AE3-208 |
| 英文同义词 | 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid;ONO-AE3-208;AE 3-208;ONO-AE3-208;AE 3-208;ONO AE3 208;AE 3-208;ONO AE3 208;Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-;4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid;4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid |
| CAS号 | 402473-54-5 |
| 分子式 | C24H21FN2O3 |
| 分子量 | 404.43 |
| EINECS号 | |
| 相关类别 | G蛋白偶联受体&G蛋白;化合物 |
| Mol文件 | 402473-54-5.mol |
| 结构式 | ![4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 结构式](CAS/GIF/402473-54-5.gif) |
4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 性质
| 沸点 | 662.4±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.30 |
| 储存条件 | -20°C |
| 溶解度 | DMSO 中≥40.4 mg/mL，温和加热；不溶于水； ≥8.1 mg/mL，乙醇溶液，温和加热和超声波 |
| 酸度系数(pKa) | 4.69±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
|
EP4
|
ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.
ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-50901 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 ONO-AE3-208 | 402473-54-5 | 2mg | 850元 |
| 2024/01/25 | HY-50901 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 ONO-AE3-208 | 402473-54-5 | 10mM * 1mLin DMSO | 1157元 |