SMER28
| 中文名称 | SMER28 |
|---|---|
| 中文同义词 | 6-溴-N-2-丙烯-1-基-4-喹唑啉胺;中文同义词:6-溴-N-2-丙烯-1-基-4-喹唑啉胺;N-烯丙基-6-溴喹唑啉-4-胺;化合物SMER28 |
| 英文名称 | SMER 28 |
| 英文同义词 | SMER 28;6-BroMo-N-2-propen-1-yl-4-quinazolinaMine;6-BroMo-N-2-propenyl-4-QuinazolinaMine;6-Bromo-N-prop-2-enylquinazolin-4-amine;SMER28 - CAS 307538-42-7 - Calbiochem;CS-2308;SMER-28;SMER 28;4-Quinazolinamine, 6-bromo-N-2-propen-1-yl- |
| CAS号 | 307538-42-7 |
| 分子式 | C11H10BrN3 |
| 分子量 | 264.12 |
| EINECS号 | |
| 相关类别 | 抑制剂;标准品;API |
| Mol文件 | 307538-42-7.mol |
| 结构式 |  |
SMER28 性质
| 熔点 | 171-173 °C |
|---|---|
| 沸点 | 391.6±32.0 °C(Predicted) |
| 密度 | 1.520±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.12±0.50(Predicted) |
| 颜色 | 米色 |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月。 |
SMER28 是一个调节自噬的、独立于 mTOR 信号通路机制的小分子阳性调节剂，能够阻止β淀粉样蛋白肽的累积。
SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability.
Cell Viability Assay
| Cell Line: | MMS1 cells |
| Concentration: | 5, 25, 50, 75, 100, 150, 200 μM |
| Incubation Time: | 24 hours |
| Result: | Showed a dose dependent decline of cell viability. |
SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg.
| Animal Model: | 14 to 16 weeks male mice (Balb/c) |
| Dosage: | 15, 65 mg/kg |
| Administration: | Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days) |
| Result: | Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100200 | SMER28 | 1 mg | 250元 | |
| 2024/01/25 | HY-100200 | SMER28 SMER28 | 307538-42-7 | 5mg | 500元 |