2-甲基-5-(1-甲基乙基)-2,5-环己二烯-1,4-二酮 1-[O-(2-甲基苯甲酰)肟]
| 中文名称 | 2-甲基-5-(1-甲基乙基)-2,5-环己二烯-1,4-二酮 1-[O-(2-甲基苯甲酰)肟] |
|---|---|
| 中文同义词 | 2-甲基-5-(1-甲基乙基)-2,5-环己二烯-1,4-二酮 1-[O-(2-甲基苯甲酰)肟];POLO-LIKE KINASE1(PLK1)抑制剂(POLOXIN);化合物POLOXIN |
| 英文名称 | 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime] |
| 英文同义词 | 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 1-[O-(2-methylbenzoyl)oxime];Poloxin;2-Methyl-5-(1-methylethyl)-1-[O-(2-methylbenzoyl)oxime]-2,5-Cyclohexadiene-1,4-dione;(Z)-2-Isopropyl-5-methyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dienone;Polo-like Kinase Inhibitor V, Poloxin;Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem;2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)-, 1-[O-(2-methylbenzoyl)oxime];2-Isopropyl-5-methyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dien-1-one |
| CAS号 | 321688-88-4 |
| 分子式 | C18H19NO3 |
| 分子量 | 297.35 |
| EINECS号 | |
| 相关类别 | 细胞周期;细胞生物学试剂 |
| Mol文件 | 321688-88-4.mol |
| 结构式 | ![2-甲基-5-(1-甲基乙基)-2,5-环己二烯-1,4-二酮 1-[O-(2-甲基苯甲酰)肟] 结构式](CAS/GIF/321688-88-4.gif) |
2-甲基-5-(1-甲基乙基)-2,5-环己二烯-1,4-二酮 1-[O-(2-甲基苯甲酰)肟] 性质
| 沸点 | 418.6±55.0 °C(Predicted) |
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| 密度 | 1.11 |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：可溶5mg/mL（透明溶液，加热） |
| 形态 | 黄色固体 |
| 颜色 | 白色至米色 |
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PLK1 PBD 4.8 μM (IC 50 ) |
PLK2 PBD 18.7 μM (IC 50 ) |
PLK3 PBD 53.9 μM (IC 50 ) |
Poloxin (25 μM) induces defects in centrosome integrity, spindle formation, and chromosome alignment in mitosis. Centrosomal fragmentation induced by Poloxin is partially rescued by Kiz T379E. Poloxin (25 μM) activates the mitotic checkpoint, induces apoptosis and inhibits proliferation of MDA-MB-231 cells. Poloxin inhibits proliferation in both cell lines with a comparable efficiency through 72 h period. Poloxin inhibits the polo-box domain (PBD) interaction with an apparent IC 50 of ∼4.8 μM. Poloxin exhibits a loose Plk1 PBD specificity with 4-10 times higher IC 50 values for Plk2 and Plk3, and does not significantly inhibit other types of phosphopeptide-binding domains such as FHA, WW, and SH2 domains.
Poloxin (40 mg/kg) decreases the proliferation of MDA-MB-231 cells, and surpresses the growth of the tumor nude mice bearing established xenografts of MDA-MB-231.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12134 | Poloxin | 5 mg | 360元 | |
| 2024/01/25 | HY-12134 | 2-甲基-5-(1-甲基乙基)-2,5-环己二烯-1,4-二酮 1-[O-(2-甲基苯甲酰)肟] Poloxin | 321688-88-4 | 10 mg | 577元 |