AP 20187
中文名称 | AP 20187 |
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中文同义词 | 化合物AP20187;AP 20187,蛋白质二聚化的化学诱导剂 |
英文名称 | AP20187 |
英文同义词 | AP20187;AP20187;AP-20187;AP 20187;AP20187 (AP-20187;(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate);B/B Homodimerizer;(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[[2-[[[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]methyl]-3-(dimethylamino)propyl]amino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate;(S,2S,2'S)-(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate);(1S,1'S)-(((2,2'-((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(acetyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-(2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate) |
CAS号 | 195514-80-8 |
分子式 | C82H107N5O20 |
分子量 | 1482.75 |
EINECS号 | |
相关类别 | 抑制剂 |
Mol文件 | 195514-80-8.mol |
结构式 |
AP 20187 性质
沸点 | 1333.5±65.0 °C(Predicted) |
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密度 | 1.192±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C,protect from light |
溶解度 | DMSO 中≥74.14 mg/mL; ≥100 mg/mL,乙醇溶液 |
形态 | 固体 |
酸度系数(pKa) | 13.97±0.46(Predicted) |
FKBP homodimerizer
When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced, and the smaller processed active caspase-9 becomes apparent.
Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-13992 | AP 20187 AP20187 | 195514-80-8 | 1mg | 1080元 |
2024/01/25 | HY-13992 | AP 20187 AP20187 | 195514-80-8 | 5mg | 2700元 |