389574-20-3
| 中文名称 | 389574-20-3 |
|---|---|
| 中文同义词 | 马来酸普拉格雷;化合物 T16572 |
| 英文名称 | Prasugrel (Maleic acid) |
| 英文同义词 | Prasugrel (Maleic acid);PCR 4099 (Maleic acid) |
| CAS号 | 389574-20-3 |
| 分子式 | C24H24FNO7S |
| 分子量 | 489.5132632 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 389574-20-3.mol |
| 结构式 |  |
389574-20-3 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
Prasugrel (PCR 4099) Maleic acid，一种噻吩吡啶和前药，抑制血小板功能。Prasugrel Maleic acid 是一种有效的 P2Y12 受体拮抗剂，抑制 ADP 诱导的血小板聚集。
P2Y12 receptor
In rat platelets, Prasugrel (PCR 4099) Maleic acid active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC
50
value of 1.8 μM.
Prasugrel (PCR 4099) Maleic acid acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel hydrochloride is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel (PCR 4099) Maleic acid is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h.
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