- UNC 669
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- $1.00 / 1g
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2019-12-24
- CAS:314241-44-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| | UNC 669 Basic information |
| Product Name: | UNC 669 | | Synonyms: | UNC 669;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone;UNC699;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669;UNC669, >=98%;(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone;CS-1146;UNC 669; UNC-669 | | CAS: | 1314241-44-5 | | MF: | C15H20BrN3O | | MW: | 338.24 | | EINECS: | | | Product Categories: | API;Inhibitors | | Mol File: | 1314241-44-5.mol |  |
| | UNC 669 Chemical Properties |
| Boiling point | 458.0±45.0 °C(Predicted) | | density | 1.424±0.06 g/cm3(Predicted) | | storage temp. | Store at -20° C | | solubility | insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO | | form | solid | | pka | 9.78±0.20(Predicted) |
| | UNC 669 Usage And Synthesis |
| Uses | (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT). | | Definition | ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid. | | Biological Activity | unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1] | | target | L3MBTL1 | | references | 1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16. |
| | UNC 669 Preparation Products And Raw materials |
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