2'MEO6MF
| 中文名称 | 2'MEO6MF |
|---|---|
| 中文同义词 | 化合物2'MEO6MF;2-(2-甲氧苯基)-6-甲基-4H-苯并吡喃-4-酮;2-(2-甲氧基苯基)-6-甲基-4H-苯并吡喃-4-酮 |
| 英文名称 | 2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE |
| 英文同义词 | 2-(2-METHOXYPHENYL)-6-METHYL-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2-(2-methoxyphenyl)-6-methyl-;2'MeO6MF;Gamma-aminobutyric acid Receptor,2'MeO-6MF,α2β2/3γ2L,γ-Aminobutyric acid Receptor,inhibit,GABAA,inflammatory,2'MeO6MF,GABA Receptor,α2β1γ2L,Inhibitor,sedative,neuroprotection,anxiolytic,stroke,α2β2/3;6-Methyl-2’-methoxyflavone;2'MeO6MF;2-(2-Methoxyphenyl)-6-methyl-4H-chromen-4-one |
| CAS号 | 89112-85-6 |
| 分子式 | C17H14O3 |
| 分子量 | 266.29 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 89112-85-6.mol |
| 结构式 |  |
2'MEO6MF 性质
GABA A receptor
2'MeO6MF (100-300 µM; 60 min) weakly displaces [
3
H]-flunitrazepam binding to rat brain synaptosomal membranes by 5-10%. 2'MeO6MF enhances [
3
H]-muscimol binding to rat brain synaptic membranes in a concentration-dependent manner yielding a mean E
max
of 219.8% and apparent EC
50
=20.8 nM.
2'MeO6MF (1-300 µM) enhances the response elicited by a low concentration of GABA in a concentration-dependent manner at recombinant α1β2γ2L GABA
A
receptors expressed in
XenopusM
oocytes. 2'MeO6MF enhances the response elicited by GABA at recombinant α1β1,3γ2L and α1β2 GABA
A
receptors without any direct activation.
2'MeO6MF (1-10 µM; 60 min) increases tonic inhibitory currents in a concentration-dependent manner in granule cells.
2'MeO6MF (100-1000 µM; 6.5 h) inhibits the LPS-induced increase of NFkB activity in RAWblue
TM
macrophage cells.
2'MeO6MF (1-100 mg/kg; i.p.) displays anxiolytic-like effects in the elevated plus maze and light/dark tests. 2'MeO6MF induces sedative effects at higher doses in the holeboard, actimeter and barbiturate-induced sleep time tests.
2'MeO6MF (30 mg/kg; i.p.) increases tonic currents in layer 2/3 pyramidal neurons of mice after stroke.
2'MeO6MF (0.1-30 mg/kg; i.p.) is neuroprotective and enhances functional recovery after focal cerebral ischaemia in mice.
| Animal Model: | Male Balb-c mice (8-10 weeks, 25-35 g) |
| Dosage: | 1, 10, 30, 100 mg/kg |
| Administration: | I.p. |
| Result: |
No overt acute toxicity was observed.
Exerted anxiolytic effects at low doses and sedative effects at high doses without myorelaxant effects. |