2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
中文名称 | 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide |
---|---|
中文同义词 | 化合物 T27554;化合物HS38;2-((1-(3-氯苯基)-4-氧代-4,5-二氢-1H-吡唑并[3,4-D]嘧啶-6-基)硫基)丙酰胺;HS 38,ATP竞争性DAPK和ZIPK抑制剂 |
英文名称 | 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide |
英文同义词 | 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide;2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide;HS38;NASYEGAVCTZSDO-UHFFFAOYSA-N;HS-38 (HS38);Propanamide, 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-;HS38 >=95% (HPLC);2-((1-(3-Chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)propanamide |
CAS号 | 1030203-81-6 |
分子式 | C14H12ClN5O2S |
分子量 | 349.8 |
EINECS号 | |
相关类别 | |
Mol文件 | 1030203-81-6.mol |
结构式 |
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide 性质
沸点 | 615.0±65.0 °C(Predicted) |
---|---|
密度 | 1.65±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:可溶5mg/mL,澄清(加热) |
酸度系数(pKa) | 14.95±0.50(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
Kd: 300 nM (DAPK1), 79 nM (DAPK2), 280 nM (ZIPK), IC50: 200 nM (DAPK1), 200 nM (PIM3)
HS38 displays high affinity toward DAPK2, with a K
d
of 79 nM. DAPK2 is not implicated in smooth muscle contractility.
HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells.
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue.
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca
2+
-sensitized rabbit ileum.
Western Blot Analysis
Cell Line: | CA-VSMCs |
Concentration: | 10 µM |
Incubation Time: | 40 minutes |
Result: | Reduced relative RLC20 phosphorylation in both the basal and S1P activated states. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-15847 | 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide HS38 | 1030203-81-6 | 5mg | 550元 |
2024/08/19 | HY-15847 | HS38 | 10 mM * 1 mLin DMSO | 605元 |