血卟啉二盐酸盐
| 中文名称 | 血卟啉二盐酸盐 |
|---|---|
| 中文同义词 | 血卟啉IX二氯化氢;卤代卟啉盐酸盐;血卟啉二盐酸盐;二盐酸血紫素;血卟啉盐酸盐;血卟啉盐酸盐(一水);血紫素盐酸盐;盐酸血紫素 |
| 英文名称 | HEMATOPORPHYRIN DIHYDROCHLORIDE |
| 英文同义词 | 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRIN IX DIHYDROCHLORIDE;HEMATOPORPHYRIN DIHYDROCHLORIDE;HAEMATOPORPHYRIN DIHYDROCHLORIDE |
| CAS号 | 17696-69-4 |
| 分子式 | C34H39ClN4O6 |
| 分子量 | 635.16 |
| EINECS号 | 241-699-4 |
| 相关类别 | 医药原料;Natural Porphyrins and Derivitives;Porphyrins;Biochemistry;Miscellaneous Biochemicals;porphine (porphyrin) ligand |
| Mol文件 | 17696-69-4.mol |
| 结构式 |  |
血卟啉二盐酸盐 性质
| 储存条件 | Inert atmosphere,Room Temperature |
|---|---|
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 深红色 |
| 水溶解性 | Insoluble in water. Soluble in pyridine (5%). |
| Merck | 14,4636 |
| BRN | 78957 |
| 稳定性 | 吸湿性 |
| EPA化学物质信息 | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
有研究表明血卟啉二盐酸盐可用于制备具有高结晶速率的树脂组合物，其包含聚呋喃二甲酸亚烷基酯(polyalkylenefurandicarboxylate)树脂和卟啉化合物。该聚呋喃二甲酸亚烷基酯树脂优选为聚呋喃二甲酸亚丁基酯树脂。该卟啉化合物优选为血卟啉二盐酸盐(hematoporphyrindihydrochloride)。Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一种光敏剂，是血红素结合蛋白亲和色谱底物。当暴露于红光下时，Hematoporphyrin dihydrochloride 可以诱导 U87 胶质瘤细胞凋亡，并降低体内肿瘤的生长。
Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC
50
s of 85 and 166 nM, respectively.
Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.
Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation.
Cell Viability Assay
| Cell Line: | U87 and U251 cells |
| Concentration: | 20, 40, 60, 80, 100, 120 nM |
| Incubation Time: | 60 min |
| Result: |
Inhibited cell viability in a dose-dependent manner.
Was more effective under the red light than white light. |
Apoptosis Analysis
| Cell Line: | U87 cells |
| Concentration: | 85 nM |
| Incubation Time: | 60 min |
| Result: |
Induced apoptotic nuclei in U87 cells with low cell density.
Induced the ROS and decreased the mitochondrial membrane potential. |
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.
| Animal Model: | Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130 |
| Dosage: | 5, 10 mg/kg |
| Administration: | I.p. daily during the initial 10 days and biweekly for the next 2 months |
| Result: |
No tumor could be palpated a few days after exposure of the rats to light.
The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40). |
安全信息
| 危险类别码 | 33 |
|---|---|
| RTECS号 | TS5505000 |
| TSCA | Yes |
| 毒性 | mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B0754A | 血卟啉二盐酸盐 Hematoporphyrin dihydrochloride | 17696-69-4 | 100mg | 900元 |
| 2024/01/16 | A18579 | 血卟啉二盐酸盐 Hematoporphyrin dihydrochloride | 17696-69-4 | 1g | 3847元 |